Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581167 | 0.86 | ALDH1A1 (0.55) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL7354403 | 0.79 | POLB (1.00) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL1179183 | 0.74 | KMT2A (0.47) | ALDH1A1HPGDKMT2AMEN1MAPT | |
| SCHEMBL11709198 | 0.73 | KMT2A (0.56) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL1686631 | 0.72 | FADS1 (0.59) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL23455358 | 0.72 | SMN1; SMN2 (0.55) | ALDH1A1POLBHPGDKMT2AMAPT | |
| SCHEMBL8934644 | 0.72 | POLB (0.52) | ALDH1A1POLBHPGDTDP1SMN1; SMN2 | |
| SCHEMBL11741665 | 0.72 | KMT2A (0.71) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL9628581 | 0.71 | POLB (0.51) | ALDH1A1POLBHPGDKMT2AMAPK1 | |
| SCHEMBL5788194 | 0.71 | HPGD (0.63) | ALDH1A1POLBHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156581-A1 | Aminergic pharmaceutical compositions and methods | BOARD OF TRUSTREES OF MICHIGAN STATE UNIVERSITY (US) | 2009-06-18 | — | — | US | disclosed |
| EP-1874356-A2 | AMINERGIC PHARMACEUTICAL COMPOSITIONS AND METHODS | Board of Trustees of Michigan State University (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113485-A2 | AMINERGIC PHARMACEUTICAL COMPOSITIONS AND METHODS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2006-10-26 | — | — | WO | disclosed |