Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.68 |
| ▸ | NOS3 | P29474 | 3/20 | 0.68 |
| ▸ | NOS2 | P35228 | 3/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | OGT | O15294 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17260645 | 0.83 | PDE3B (0.71) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL243203 | 0.81 | NOS1 (1.00) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL29490188 | 0.81 | NOS1 (1.00) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL4261971 | 0.81 | NOS3 (0.68) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL11256932 | 0.78 | PDE3B (0.63) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL13680565 | 0.77 | PDE3B (0.54) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL11258651 | 0.76 | PDE3B (0.68) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL11251932 | 0.76 | PDE3B (0.68) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL17260653 | 0.76 | PDE3B (0.69) | NOS1NOS3NOS2PDE3BPDE3A | |
| SCHEMBL13680594 | 0.75 | NOS1 (0.58) | NOS1NOS3NOS2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-02-26 | — | — | US | claimed |
| CN-101365696-A | Compounds and compositions as modulators of steroid hormone nuclear receptors | IRM LLC (BM) | 2009-02-11 | — | — | CN | claimed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-02-26 | — | — | US | disclosed |
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | NR5A1, ESRRA, NR3C1 | NOS1 1818/4885NOS3 1379/4885NOS2 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.