Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.73 |
| ▸ | CHKA | P35790 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HBB | P68871 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4259349 | 0.91 | CHRM5 (0.73) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| Acetonitrile SCHEMBL27605904 | 0.88 | CHRM5 (0.76) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| Water SCHEMBL27487876 | 0.88 | CHRM5 (0.94) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| Water SCHEMBL19285054 | 0.88 | CHRM5 (0.94) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| Water SCHEMBL27463458 | 0.88 | CHRM5 (0.94) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| Water SCHEMBL29850461 | 0.88 | CHRM5 (0.94) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL320245 | 0.88 | CHRM5 (0.94) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| Fluoride SCHEMBL17966130 | 0.85 | CHRM5 (0.89) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8664726 | 0.85 | CHRM5 (1.00) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL189 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220558-A1 | Methods of Treating Hormone-Related Conditions Using Thio-Oxindole Derivatives | WYETH LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-8242098-B2 | Methods of treating hormone-related conditions using thio-oxindole derivatives | WYETH LLC (US) | 2012-08-14 | — | — | US | disclosed |
| US-20090099223-A1 | METHODS OF TREATING HORMONE-RELATED CONDITIONS USING THIO-OXINDOLE DERIVATIVES | WYETH (US) | 2009-04-16 | — | — | US | disclosed |
| US-7488734-B2 | Methods of treating hormone-related conditions using thio-oxindole derivatives | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-7115649-B2 | Methods of treating skin disorders using thio-oxindole derivatives | WYETH (US) | 2006-10-03 | — | — | US | disclosed |
| US-7091234-B2 | Thio-oxindole derivatives | WYETH (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1515680-A4 | USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF SKIN DISORDERS | WYETH CORP (US) | 2005-09-21 | — | — | EP | disclosed |
| EP-1531806-A4 | USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS | WYETH CORP (US) | 2005-09-21 | — | — | EP | disclosed |
| US-6946454-B2 | Thio-oxindole derivatives | WYETH (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050171186-A1 | 3-(1',2'-Dihydro-2'-thioxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzonitrile; 5'-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3'-[3H]indol]-2'-ylidenecyanamide; progesterone receptor agonist; mixture with estrone (estrogen); hormone replacement therapy, contraception; anticarcinogenic | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2004000227-A2 | USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF SKIN DISORDERS | WYETH (US) | 2003-12-31 | — | — | WO | disclosed |
| US-20030225109-A1 | Thio-oxindole derivatives | WYETH (US) | 2003-12-04 | — | — | US | disclosed |
| US-6583145-B1 | Thio-oxindole derivatives | WYETH | 2003-06-24 | — | — | US | disclosed |
| US-6521657-B2 | Indole derivatives which are agonists of the progesterone receptor and useful for treatment of carcinoma and adenocarcinomas of uterine leiomyomata, endometriosis or polycystic ovary syndorme in a mammal | WYETH | 2003-02-18 | — | — | US | disclosed |
| US-20020169198-A1 | Thio-oxindole derivatives | WYETH (US) | 2002-11-14 | — | — | US | disclosed |
| US-20020103248-A1 | Thio-oxindole derivatives | WYETH LLC | 2002-08-01 | — | — | US | disclosed |
| CN-1349499-A | Thio-oxindole derivatives | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| US-6355648-B1 | COMPOUNDS AS CONTRACEPTIVES AND PROGESTERONE ANTAGONIST | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-12 | — | — | US | disclosed |
| EP-1181275-A1 | THIO-OXINDOLE DERIVATIVES | American Home Products Corporation (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000066555-A1 | THIO-OXINDOLE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220558-A1 | Methods of Treating Hormone-Related Conditions Using Thio-Oxindole Derivatives | OXTR, GNRHR, SHBG | CHRM5 245/4885CHKA 4759/4885MAPT 2066/4885 |
| US-20020103248-A1 | Thio-oxindole derivatives | PGR, OXTR, PGRMC1 | CHRM5 305/4885CHKA 4533/4885MAPT 3849/4885 |
| US-20030225109-A1 | Thio-oxindole derivatives | PGR, OXTR, PGRMC1 | CHRM5 318/4885CHKA 4519/4885MAPT 4187/4885 |
| US-20050171186-A1 | 3-(1',2'-Dihydro-2'-thioxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzonitrile; 5'-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3'-[3H]indol]-2'-ylidenecyanamide; progesterone receptor agonist; mixture with estrone (estrogen); hormone replacement therapy, contraception; anticarcinogenic | PGR, ESR1, PGRMC1 | CHRM5 188/4885CHKA 2970/4885MAPT 4568/4885 |
| US-20020169198-A1 | Thio-oxindole derivatives | GPER1, PGR, ESR1 | CHRM5 288/4885CHKA 4275/4885MAPT 3685/4885 |
| US-20090099223-A1 | METHODS OF TREATING HORMONE-RELATED CONDITIONS USING THIO-OXINDOLE DERIVATIVES | OXTR, GNRHR, SHBG | CHRM5 245/4885CHKA 4759/4885MAPT 2066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.