Sugi Predict

Sugi Predict / Compounds / SCHEMBL4259604

SCHEMBL4259604

SCHEMBL4259604

CCC(=O)N1CCC(C(=O)O)CC1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.54
▸ POLB P06746 2/20 0.51
▸ EPHX2 P34913 4/20 0.50
▸ LMNA P02545 1/20 0.50
▸ RIPK1 Q13546 1/20 0.46
▸ BLM P54132 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ CREBBP Q92793 1/20 0.43
▸ NPC1 O15118 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12233293 0.88 EPHX2 (0.47) L3MBTL1POLBEPHX2LMNARIPK1
SCHEMBL3288960 0.88 EPHX2 (0.47) L3MBTL1POLBEPHX2LMNARIPK1
SCHEMBL5221546 0.84 POLB (0.57) L3MBTL1POLBEPHX2LMNACREBBP
SCHEMBL12436953 0.83 EPHX2 (0.50) EPHX2RIPK1ALDH1A1NPC1
SCHEMBL12396072 0.82 GAA (0.62) EPHX2ALDH1A1RAB9ASMN1; SMN2
SCHEMBL18700234 0.82 LMNA (0.49) L3MBTL1POLBLMNAALDH1A1NPC1
SCHEMBL9280678 0.81 GNAI3 (0.57) L3MBTL1POLBALDH1A1NPC1RAB9A
SCHEMBL6974124 0.81 L3MBTL1 (0.56) L3MBTL1POLBLMNAALDH1A1CREBBP
SCHEMBL1970601 0.81 L3MBTL1 (0.56) L3MBTL1POLBLMNAALDH1A1CREBBP
SCHEMBL5606075 0.80 L3MBTL1 (0.51) L3MBTL1POLBLMNAALDH1A1CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
EP-3307738-B1 ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE UNIV MICHIGAN REGENTS (US) 2022-04-20 — — EP disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN disclosed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US disclosed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP disclosed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US disclosed
US-20090005355-A1 Piperidine Compound and Process for Preparing the Same TANABE SEIYAKU CO., LTD. (JP) 2009-01-01 — — US disclosed
US-20090005355-A1 Piperidine Compound and Process for Preparing the Same TANABE SEIYAKU CO., LTD. (JP) 2009-01-01 — — US disclosed
US-20090005355-A1 Piperidine Compound and Process for Preparing the Same TANABE SEIYAKU CO., LTD. (JP) 2009-01-01 — — US disclosed
US-7300948-B2 Alkynyl compounds as non nucleoside reverse transcriptase inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-11-27 — — US disclosed
EP-1765780-A1 PIPERIDINE COMPOUND AND PROCESS FOR PREPARING THE SAME TANABE SEIYAKU CO., LTD. (JP) 2007-03-28 — — EP disclosed
US-20070049593-A1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor JAPAN TOBACCO INC. (JP) 2007-03-01 — — US disclosed
WO-2006004195-A1 PIPERIDINE COMPOUND AND PROCESS FOR PREPARING THE SAME TANABE SEIYAKU CO., LTD. (JP) 2006-01-12 — — WO disclosed
US-5102890-A Anxiolytic agents RHONE-POULENC SANTE (FR) 1992-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070049593-A1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor POLI, TERT, ZC3HAV1 L3MBTL1 4435/4885POLB 77/4885EPHX2 2282/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A L3MBTL1 4597/4885POLB 796/4885EPHX2 1352/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A L3MBTL1 4597/4885POLB 796/4885EPHX2 1352/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A L3MBTL1 4597/4885POLB 796/4885EPHX2 1352/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A L3MBTL1 4597/4885POLB 796/4885EPHX2 1352/4885
US-20090005355-A1 Piperidine Compound and Process for Preparing the Same AVPR1B, HRH4, PRLHR L3MBTL1 4431/4885POLB 1735/4885EPHX2 2304/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A L3MBTL1 4597/4885POLB 796/4885EPHX2 1352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.