Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 12/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 10/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MCTS1 | Q9ULC4 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423612 | 0.83 | SLC16A3 (0.43) | SLC16A3SLC16A1PTGS1PTGS2L3MBTL1 | |
| SCHEMBL23142295 | 0.80 | KDM4E (0.35) | SLC16A3SLC16A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL423520 | 0.79 | KDM4E (0.35) | SLC16A3SLC16A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL31036882 | 0.79 | KDM4E (0.35) | SLC16A3SLC16A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL23142321 | 0.79 | KDM4E (0.35) | SLC16A3SLC16A1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL421921 | 0.78 | SLC16A3 (0.43) | SLC16A3SLC16A1MCTS1 | |
| SCHEMBL24948912 | 0.76 | PTGS1 (0.42) | SLC16A3SLC16A1PTGS1PTGS2L3MBTL1 | |
| SCHEMBL23142318 | 0.72 | HSD11B1 (0.39) | L3MBTL1KDM4EPOLBALDH1A1 | |
| SCHEMBL28801786 | 0.72 | KDM4E (0.37) | L3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL27877177 | 0.71 | TRPV1 (0.35) | L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340526-B2 | Process for preparing pyridyl-substituted pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| US-20150191447-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-09 | — | — | US | disclosed |
| US-8987460-B2 | Process for preparing pyridyl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2015-03-24 | — | — | US | disclosed |
| EP-2414345-B1 | Method for manufacturing Pyridyl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2014-09-17 | — | — | EP | disclosed |
| EP-2456747-B1 | Method for preparing alkoxyenones and enaminoketones | BAYER CROPSCIENCE AG (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2456760-B1 | Method for manufacturing aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2014-05-07 | — | — | EP | disclosed |
| US-20130131347-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-23 | — | — | US | disclosed |
| US-8399679-B2 | Aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8362261-B2 | Process for preparing pyridyl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2013-01-29 | — | — | US | disclosed |
| US-20130018192-A1 | Aryl-substituted Pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-01-17 | — | — | US | disclosed |
| EP-2456747-A1 | NOVEL ALKOXYENONES AND ENAMINOKETONES AND A METHOD FOR THE PRODUCTION THEREOF | Bayer CropScience AG (DE) | 2012-05-30 | — | — | EP | disclosed |
| EP-2414345-A1 | METHOD FOR PRODUCING PYRIDYL-SUBSTITUTED PYRAZOLES | Bayer CropScience AG (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20120022285-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | BAYER CROPSCIENCE AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20110087029-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-04-14 | — | — | US | disclosed |
| US-20110028729-A1 | Process for preparing aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-02-03 | — | — | US | disclosed |
| US-20110021782-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | US | disclosed |
| WO-2011009552-A1 | NOVEL ALKOXYENONES AND ENAMINOKETONES AND A METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009551-A1 | PROCESS FOR PRODUCING ARYL-SUBSTITUTED PYRAZOLES | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | WO | disclosed |
| EP-2243777-A1 | Method for manufacturing Pyridyl-substituted pyrazoles | Bayer CropScience AG (DE) | 2010-10-27 | — | — | EP | disclosed |
| WO-2010112178-A1 | METHOD FOR PRODUCING PYRIDYL-SUBSTITUTED PYRAZOLES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131347-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | PDXK, PLK2, WNK3 | SLC16A3 1755/4885SLC16A1 2255/4885PTGS1 2348/4885 |
| US-20130018192-A1 | Aryl-substituted Pyrazoles | WNK3, AHR, TYR | SLC16A3 2108/4885SLC16A1 3429/4885PTGS1 3526/4885 |
| US-20120022285-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | AKR7A2, CYP51A1, PDK3 | SLC16A3 4068/4885SLC16A1 4722/4885PTGS1 3728/4885 |
| US-20110028729-A1 | Process for preparing aryl-substituted pyrazoles | WNK3, WNK2, TYR | SLC16A3 3138/4885SLC16A1 4128/4885PTGS1 3436/4885 |
| US-20150191447-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | PDXK, PLK2, WNK3 | SLC16A3 1755/4885SLC16A1 2255/4885PTGS1 2348/4885 |
| US-20110087029-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | PDXK, PLK2, WNK3 | SLC16A3 1755/4885SLC16A1 2255/4885PTGS1 2348/4885 |
| US-20110021782-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | AKR7A2, CYP51A1, PDK3 | SLC16A3 4068/4885SLC16A1 4722/4885PTGS1 3728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.