Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23142295 | 0.87 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31036882 | 0.86 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL23142321 | 0.86 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL421921 | 0.80 | SLC16A3 (0.43) | SLC16A3SLC16A1TRPV1TRPA1 | |
| SCHEMBL423980 | 0.80 | SLC16A3 (0.39) | MEN1KMT2ASLC16A3SLC16A1TRPA1 | |
| SCHEMBL426107 | 0.79 | SLC16A3 (0.39) | KDM4EALDH1A1MAPTSLC16A3SLC16A1 | |
| Hydrochloric Acid SCHEMBL420241 | 0.78 | SLC16A3 (0.38) | MEN1KMT2ASLC16A3SLC16A1TRPA1 | |
| SCHEMBL13349718 | 0.78 | SLC16A3 (0.36) | SLC16A3SLC16A1TRPV1TRPA1 | |
| SCHEMBL28801786 | 0.78 | KDM4E (0.37) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL23142318 | 0.78 | HSD11B1 (0.39) | KDM4EALDH1A1L3MBTL1TRPV1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456747-B1 | Method for preparing alkoxyenones and enaminoketones | BAYER CROPSCIENCE AG (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2456760-B1 | Method for manufacturing aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2014-05-07 | — | — | EP | disclosed |
| US-8586753-B2 | Process for the preparation of 1-alkyl and 1-aryl-5-pyrazolecarboxylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-19 | — | — | US | disclosed |
| US-8586753-B2 | Process for the preparation of 1-alkyl and 1-aryl-5-pyrazolecarboxylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-19 | — | — | US | disclosed |
| EP-2513063-B1 | Method for manufacturing 1-alkyl-/1-aryl-5-pyrazolcarbonic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-06 | — | — | EP | disclosed |
| EP-2513063-B1 | Method for manufacturing 1-alkyl-/1-aryl-5-pyrazolcarbonic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-06 | — | — | EP | disclosed |
| US-8399679-B2 | Aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-20130018192-A1 | Aryl-substituted Pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-01-17 | — | — | US | disclosed |
| US-8299260-B2 | Process for preparing aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2012-10-30 | — | — | US | disclosed |
| CN-102753531-A | Method for producing 1-alkyl-/1-aryl-5-pyrazole-carboxylic acid derivatives | BAYER CROPSCIENCE AG | 2012-10-24 | — | — | CN | disclosed |
| EP-2456747-A1 | NOVEL ALKOXYENONES AND ENAMINOKETONES AND A METHOD FOR THE PRODUCTION THEREOF | Bayer CropScience AG (DE) | 2012-05-30 | — | — | EP | disclosed |
| US-20120022285-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | BAYER CROPSCIENCE AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20110152532-A1 | Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152532-A1 | Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152532-A1 | Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-06-23 | — | — | US | disclosed |
| WO-2011073101-A1 | METHOD FOR PRODUCING 1-ALKYL-/1-ARYL-5-PYRAZOLE-CARBOXYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| US-20110028729-A1 | Process for preparing aryl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-02-03 | — | — | US | disclosed |
| US-20110021782-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | US | disclosed |
| WO-2011009552-A1 | NOVEL ALKOXYENONES AND ENAMINOKETONES AND A METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009551-A1 | PROCESS FOR PRODUCING ARYL-SUBSTITUTED PYRAZOLES | BAYER CROPSCIENCE AG (DE) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018192-A1 | Aryl-substituted Pyrazoles | WNK3, AHR, TYR | KDM4E 1967/4885MEN1 3820/4885ALDH1A1 316/4885 |
| US-20120022285-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | AKR7A2, CYP51A1, PDK3 | KDM4E 475/4885MEN1 2076/4885ALDH1A1 1049/4885 |
| US-20110152532-A1 | Process For The Preparation Of 1-Alkyl And 1-Aryl-5-pyrazolecarboxylic Acid Derivatives | AADAC, CYP4X1, CYP4Z1 | KDM4E 1594/4885MEN1 3332/4885ALDH1A1 317/4885 |
| US-20110028729-A1 | Process for preparing aryl-substituted pyrazoles | WNK3, WNK2, TYR | KDM4E 1719/4885MEN1 3703/4885ALDH1A1 556/4885 |
| US-20110021782-A1 | Novel alkoxy enones and enamino ketones and a process for preparation thereof | AKR7A2, CYP51A1, PDK3 | KDM4E 475/4885MEN1 2076/4885ALDH1A1 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.