Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2980048 | 0.99 | HPGDS (0.49) | HPGDSBAZ2AMEN1KMT2ANPY5R | |
| SCHEMBL2984450 | 0.78 | CHRM4 (0.36) | BAZ2ANPY5R | |
| SCHEMBL2984991 | 0.76 | ALDH1A1 (0.40) | BAZ2ANPY5RKCNH2TLR9TLR8 | |
| SCHEMBL4262100 | 0.74 | HPGDS (0.59) | HPGDSBAZ2AMEN1KMT2ANPC1 | |
| SCHEMBL13422226 | 0.74 | HPGDS (0.52) | HPGDSBAZ2AMEN1KMT2AAOC3 | |
| SCHEMBL1042507 | 0.74 | HPGDS (0.47) | HPGDSBAZ2AMEN1KMT2AAOC3 | |
| SCHEMBL4265265 | 0.74 | HPGDS (0.61) | HPGDSBAZ2AMEN1KMT2AAOC3 | |
| Bromide SCHEMBL2983628 | 0.73 | HPGDS (0.57) | HPGDSBAZ2AMEN1KMT2ANPC1 | |
| Bromide SCHEMBL2984301 | 0.72 | HPGDS (0.60) | HPGDSBAZ2AMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL17541611 | 0.72 | HPGDS (0.46) | HPGDSBAZ2AMEN1KMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |
| CN-101243078-A | Thiazolyl piperidine derivatives useful as h3 receptor modulators | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |