Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 3/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260608 | 0.86 | MAPT (0.48) | MEN1KMT2AMAPTRECQLPIN1 | |
| SCHEMBL7321600 | 0.83 | KMO (0.59) | KMOFOLH1CPA1PPARAPPARG | |
| SCHEMBL14309587 | 0.82 | KMO (0.46) | KMOFOLH1PIN1PPARAPPARG | |
| SCHEMBL3961471 | 0.82 | FOLH1 (0.62) | MEN1KMT2AMAPTFOLH1PIN1 | |
| SCHEMBL3961475 | 0.82 | FOLH1 (0.62) | MEN1KMT2AMAPTFOLH1PIN1 | |
| SCHEMBL3961470 | 0.82 | FOLH1 (0.62) | MEN1KMT2AMAPTFOLH1PIN1 | |
| SCHEMBL7315058 | 0.81 | PDPK1 (0.60) | KMOFOLH1MMECPA1PPARA | |
| SCHEMBL5808951 | 0.77 | HTR2A (0.50) | MEN1KMT2AMAPTCPA1PPARA | |
| SCHEMBL14193135 | 0.77 | KMO (0.41) | KMOFOLH1PIN1MMECPA1 | |
| SCHEMBL5095202 | 0.77 | PPARA (0.64) | MAPTPPARAPPARGHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082392-A1 | Substituted Carboxylic Acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2009-03-26 | — | — | US | disclosed |
| US-7358364-B2 | treatment of diabetes and/or cancer; useful in the treatment of syndrome X; capable of inhibiting Protein tyrosine phosphatase | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1805159-A1 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| CN-1812977-A | Substituted carboxylic acids | INST PHARMACEUTICAL DISCOVERY (US) | 2006-08-02 | — | — | CN | disclosed |
| WO-2006050212-A1 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060094747-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2006-05-04 | — | — | US | disclosed |
| EP-1620420-A2 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20040266788-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-30 | — | — | US | disclosed |
| WO-2004099168-A2 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266788-A1 | Substituted carboxylic acids | PTP4A1, PTPRS, G6PC1 | MEN1 2359/4885KMT2A 2771/4885MAPT 1123/4885 |
| US-20060094747-A1 | Substituted carboxylic acids | PTPRS, PTPRO, PTPRJ | MEN1 2928/4885KMT2A 2422/4885MAPT 1249/4885 |
| US-20090082392-A1 | Substituted Carboxylic Acids | PTPRJ, PTPRS, PTPRG | MEN1 3127/4885KMT2A 2575/4885MAPT 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.