Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | UBE2N | P61088 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110383 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL4264289 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL7439781 | 0.78 | GAA (0.60) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL1944405 | 0.78 | ADORA2B (1.00) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL2795748 | 0.76 | POLB (0.75) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL22521806 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL7113737 | 0.76 | PNP (0.59) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL11014928 | 0.76 | POLB (0.83) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL23974582 | 0.75 | SMN1; SMN2 (0.80) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A | |
| SCHEMBL27794931 | 0.75 | POLB (0.73) | SMN1; SMN2RXFP1ADORA2BPOLBHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |