SCHEMBL4264413

SCHEMBL4264413

O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C#CCCO

nearest known ligand 0.77

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TK1 P04183 3/20 0.64
LMNA P02545 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
ALOX12 P18054 1/20 0.60
ADRA1A P35348 1/20 0.60
TK2 O00142 1/20 0.59
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
TSHR P16473 1/20 0.58
BLM P54132 1/20 0.58
PMP22 Q01453 1/20 0.58
NPSR1 Q6W5P4 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4264417 1.00 TK1 (0.64) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL7166600 0.94 TK1 (0.61) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL7166605 0.94 TK1 (0.61) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL7173806 0.93 TK1 (0.60) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL7173802 0.93 TK1 (0.60) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL7168840 0.92 TK1 (0.59) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL7168837 0.92 TK1 (0.59) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL933039 0.92 TK1 (0.66) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL933041 0.92 TK1 (0.66) TK1LMNASMN1; SMN2ALOX12ADRA1A
SCHEMBL4274511 0.91 TK1 (0.66) TK1LMNASMN1; SMN2ALOX12ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119546776-A Variant allele enrichment by unidirectional double probe primer extension 豪夫迈·罗氏有限公司 2025-02-28 CN disclosed
CN-119325511-A Methods, compositions and kits for inhibiting linker dimer formation 柏尔科学公司 2025-01-17 CN disclosed
CN-118355129-A Method for capturing CRISPR endonuclease cleavage products 卡里布生物科学公司 2024-07-16 CN disclosed
CN-117859062-A Multiple assay plate and method of making same 中尺度技术有限责任公司 2024-04-09 CN disclosed
WO-2024073740-A2 IMPROVED LOOP–MEDIATED ISOTHERMAL AMPLIFICATION METHODS, COMPOSITIONS, KITS, AND SYSTEMS FOR DETECTING NUCLEIC ACIDS 3EO HEALTH INC. (US) 2024-04-04 WO disclosed
CN-117730155-A Enhancer oligonucleotides for nucleic acid hybridization 豪夫迈·罗氏有限公司 2024-03-19 CN disclosed
CN-116964221-A Structure for preventing nucleic acid templates from passing through nanopores during sequencing 豪夫迈·罗氏有限公司 2023-10-27 CN disclosed
CN-116368236-A Polynucleotide array 牛津大学创新有限公司 2023-06-30 CN disclosed
CN-116348614-A Switching oligonucleotides 牛津大学创新有限公司 2023-06-27 CN disclosed
CN-115968409-A Compositions and methods for sequencing using polymer bridges 伊鲁米纳公司 2023-04-14 CN disclosed
US-6339151-B1 FORMING COMPOUNDS USING A NUCLEIC ACID BASE WITH A PHOSPHOROUS HALIDE TO FORM DRUGS FOR NONPROLIFERATION OF CELLS NEWBIOTICS, INC. 2002-01-15 US disclosed
EP-1167972-A2 Enzyme catalyzed therapeutic agents Newbiotics Inc. (US) 2002-01-02 EP disclosed
US-20010034440-A1 Enzyme catalyzed therapeutic agents KIADIS PHARMA INTELLECTUAL PROPERTY B.V. (NL) 2001-10-25 US disclosed
US-6245750-B1 THYMIDINE PHOSPHORAMIDE DERIVATIVE; ANTIPROLIFERATIVE, ANTICARCINOGENIC AGENTS; ENZYME INHIBITORS; NEWBIOTICS, INC. 2001-06-12 US disclosed
WO-2001007087-A2 ENZYME CATALYZED ANTI-INFECTIVE THERAPEUTIC AGENTS NEWBIOTICS, INC. (US) 2001-02-01 WO disclosed
WO-2001007088-A2 METHODS FOR TREATING THERAPY-RESISTANT TUMORS NEWBIOTICS, INC. (US) 2001-02-01 WO disclosed
WO-2001007454-A1 ENZYME CATALYZED THERAPEUTIC ACTIVATION NEWBIOTICS, INC. (US) 2001-02-01 WO disclosed
EP-1045897-A4 ENZYME CATALYZED THERAPEUTIC AGENTS NEWBIOTICS INC (US) 2000-10-25 EP disclosed
EP-1045897-A1 ENZYME CATALYZED THERAPEUTIC AGENTS Newbiotics Inc. (US) 2000-10-25 EP disclosed
WO-1999037753-A1 ENZYME CATALYZED THERAPEUTIC AGENTS NEWBIOTICS, INC. (US) 1999-07-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034440-A1 Enzyme catalyzed therapeutic agents DNPEP, AGBL2, ENTPD2 TK1 7/4885LMNA 2990/4885SMN1; SMN2 3906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.