Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.41 |
| ▸ | MAOA | P21397 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | FCGR3B | O75015 | 1/20 | 0.35 |
| ▸ | FCGR1A | P12314 | 1/20 | 0.35 |
| ▸ | FCGR2A | P12318 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 2/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266791 | 0.85 | SMN1; SMN2 (0.45) | NFKB1NFKB2RELAHRH4HRH3 | |
| SCHEMBL4259572 | 0.83 | HRH4 (0.42) | NFKB1NFKB2RELAHRH4HRH3 | |
| SCHEMBL4274502 | 0.83 | LMNA (0.41) | NFKB1NFKB2RELAHRH4HRH3 | |
| SCHEMBL4266993 | 0.83 | POLB (0.40) | NFKB1NFKB2RELAHRH4HRH3 | |
| SCHEMBL4260830 | 0.83 | F2 (0.50) | MAOBMAOANFKB1NFKB2RELA | |
| SCHEMBL4260835 | 0.82 | NFKB1 (0.57) | NFKB1NFKB2RELAFCGR3BFCGR1A | |
| SCHEMBL4260026 | 0.82 | HRH4 (0.41) | NFKB1NFKB2RELAHRH4HRH3 | |
| SCHEMBL4269566 | 0.81 | TSHR (0.41) | NFKB1NFKB2RELAHRH4HRH3 | |
| SCHEMBL4264695 | 0.76 | HTT (0.53) | NFKB1NFKB2RELAAPP | |
| SCHEMBL21436684 | 0.69 | APP (0.49) | HRH4APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082371-A1 | Treatment of Viral Disease and Cancer With Nf-kappaB Inhibitors | LU ZHIMIN | 2009-03-26 | — | — | US | claimed |
| US-20090082371-A1 | Treatment of Viral Disease and Cancer With Nf-kappaB Inhibitors | LU ZHIMIN | 2009-03-26 | — | — | US | disclosed |
| CN-101269077-A | Use of NF-kB inhibitors for treating retroviral infections | ZHIMIN LU (CN) | 2008-09-24 | — | — | CN | disclosed |
| CN-100418532-C | NF-kB compound inhibitor for treating various diseases | ZHIMIN LU (CN) | 2008-09-17 | — | — | CN | disclosed |
| CN-101239056-A | Use of NF-kB inhibitors for treating various diseases | ZHIMIN LU (CN) | 2008-08-13 | — | — | CN | disclosed |
| CN-1709259-A | Use of NF-kB inhibitors in the treatment of various diseases | LU ZHIMIN (CN) | 2005-12-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082371-A1 | Treatment of Viral Disease and Cancer With Nf-kappaB Inhibitors | RELA, NFKBIA, NFKB1 | MAOB 4484/4885MAOA 3475/4885ACHE 3264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.