Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260026 | 0.99 | HRH4 (0.41) | TSHRHRH4HRH3TLR8TLR7 | |
| SCHEMBL4259572 | 0.97 | HRH4 (0.42) | HRH4HRH3TLR8TLR7PKM | |
| SCHEMBL4274502 | 0.93 | LMNA (0.41) | HRH4HRH3TLR8TLR7PKM | |
| SCHEMBL4264697 | 0.81 | MAOB (0.41) | HRH4HRH3CA1CA2CA9 | |
| SCHEMBL4260830 | 0.81 | F2 (0.50) | RAB9ANFKB1NFKB2RELAMEN1 | |
| SCHEMBL4269556 | 0.77 | HTT (0.52) | MEN1LMNAMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL4260015 | 0.76 | HTT (0.52) | MEN1LMNAMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL27873830 | 0.72 | EGFR (0.47) | TLR8TLR7 | |
| SCHEMBL8942880 | 0.71 | MEN1 (0.61) | TSHRS1PR1S1PR4S1PR3S1PR5 | |
| SCHEMBL28490262 | 0.71 | NPC1 (0.56) | TSHRS1PR1S1PR4S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082371-A1 | Treatment of Viral Disease and Cancer With Nf-kappaB Inhibitors | LU ZHIMIN | 2009-03-26 | — | — | US | claimed |
| US-20090082371-A1 | Treatment of Viral Disease and Cancer With Nf-kappaB Inhibitors | LU ZHIMIN | 2009-03-26 | — | — | US | disclosed |
| CN-101269077-A | Use of NF-kB inhibitors for treating retroviral infections | ZHIMIN LU (CN) | 2008-09-24 | — | — | CN | disclosed |
| CN-100418532-C | NF-kB compound inhibitor for treating various diseases | ZHIMIN LU (CN) | 2008-09-17 | — | — | CN | disclosed |
| CN-101239056-A | Use of NF-kB inhibitors for treating various diseases | ZHIMIN LU (CN) | 2008-08-13 | — | — | CN | disclosed |
| CN-1709259-A | Use of NF-kB inhibitors in the treatment of various diseases | LU ZHIMIN (CN) | 2005-12-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082371-A1 | Treatment of Viral Disease and Cancer With Nf-kappaB Inhibitors | RELA, NFKBIA, NFKB1 | TSHR 4857/4885HRH4 2051/4885HRH3 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.