Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264983 | 1.00 | LMNA (0.50) | LMNASMN1; SMN2CYP1A2CYP2D6HTT | |
| SCHEMBL4260562 | 0.88 | CARM1 (0.45) | LMNASMN1; SMN2CYP1A2CYP2D6HTT | |
| SCHEMBL4260567 | 0.88 | CARM1 (0.45) | LMNASMN1; SMN2CYP1A2CYP2D6HTT | |
| SCHEMBL4257832 | 0.84 | MCHR1 (0.43) | LMNASMN1; SMN2CYP1A2CYP2D6HTT | |
| SCHEMBL4257825 | 0.84 | MCHR1 (0.43) | LMNASMN1; SMN2CYP1A2CYP2D6HTT | |
| SCHEMBL4260882 | 0.83 | ALDH1A1 (0.52) | LMNAMCHR1KDM4E | |
| SCHEMBL4260890 | 0.83 | ALDH1A1 (0.52) | LMNAMCHR1KDM4E | |
| SCHEMBL4263749 | 0.83 | MCHR1 (0.53) | MCHR1ACHEBACE1CCNT1BCHE | |
| SCHEMBL4263752 | 0.83 | MCHR1 (0.53) | MCHR1ACHEBACE1CCNT1BCHE | |
| Trifluoroacetic Acid SCHEMBL4262316 | 0.82 | MCHR1 (0.40) | LMNASMN1; SMN2CYP1A2CYP2D6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | LMNA 2888/4885SMN1; SMN2 898/4885CYP1A2 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.