Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266919 | 0.86 | MAPT (0.42) | MAPTGAAESR1L3MBTL1TDP1 | |
| SCHEMBL4419566 | 0.86 | CES1 (0.37) | MAPTL3MBTL1TDP1CES1MEN1 | |
| SCHEMBL4551674 | 0.86 | MAPT (0.37) | MAPTCES1MEN1KMT2AGABRA1 | |
| SCHEMBL4412532 | 0.85 | MAPT (0.43) | MAPTGAAESR1L3MBTL1TDP1 | |
| SCHEMBL4412530 | 0.85 | MAPT (0.43) | MAPTGAAESR1L3MBTL1TDP1 | |
| SCHEMBL4263583 | 0.85 | L3MBTL1 (0.50) | MAPTGAAESR1L3MBTL1TDP1 | |
| SCHEMBL4273001 | 0.81 | CYP1A2 (0.37) | ALDH1A1MEN1KMT2AAKR1B1ACHE | |
| SCHEMBL4269415 | 0.81 | TRPM8 (0.50) | MAPTGAAESR1L3MBTL1TDP1 | |
| SCHEMBL4551139 | 0.79 | ESR1 (0.50) | MAPTGAAESR1L3MBTL1TDP1 | |
| SCHEMBL4264174 | 0.79 | ESR1 (0.50) | MAPTGAAESR1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009110002-A1 | NOVEL EFFLUX PUMP INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-09-11 | — | — | WO | claimed |
| WO-2009110002-A1 | NOVEL EFFLUX PUMP INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-09-11 | — | — | WO | disclosed |