Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266234 | 0.79 | MEN1 (0.41) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28282975 | 0.79 | ESR2 (0.42) | ALDH1A1KDM4EHSD17B10TSHRGAA | |
| SCHEMBL2650416 | 0.74 | ESR2 (0.48) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9069185 | 0.73 | ESR2 (0.47) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29468705 | 0.72 | DYRK1A (0.38) | ALDH1A1KDM4EHSD17B10TSHRGAA | |
| SCHEMBL28315214 | 0.72 | DYRK1A (0.38) | ALDH1A1KDM4EHSD17B10TSHRGAA | |
| SCHEMBL4266237 | 0.72 | ADORA1 (0.41) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL27701462 | 0.71 | TSHR (0.47) | ALDH1A1KDM4EHSD17B10TSHRGAA | |
| SCHEMBL6085223 | 0.70 | ALDH1A1 (0.40) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL27346612 | 0.70 | KCNH2 (0.34) | ALDH1A1KDM4EHSD17B10TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227648-A1 | PYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER | ASTRAZENECA AB | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227648-A1 | PYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER | TP53, PDK2, PDK1 | CYP11B1 40/4885CYP11B2 18/4885ALDH1A1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.