Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.34 |
| ▸ | HTR1B | P28222 | 8/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 4/20 | 0.30 |
| ▸ | HTR2C | P28335 | 4/20 | 0.30 |
| ▸ | HTR2B | P41595 | 4/20 | 0.30 |
| ▸ | HTR1A | P08908 | 3/20 | 0.30 |
| ▸ | HTR6 | P50406 | 2/20 | 0.30 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978270 | 0.77 | MEN1 (0.41) | HTR1DHTR1BCREBBPMEN1KMT2A | |
| SCHEMBL6092206 | 0.74 | HTR1D (0.47) | HTR1DHTR1BMEN1KMT2AHTR2A | |
| SCHEMBL3900178 | 0.68 | ADRA2A (0.39) | CREBBPHTR1AADRA2AADRA2C | |
| SCHEMBL2043007 | 0.68 | OXTR (0.38) | HTR1DHTR1BHTR6 | |
| SCHEMBL2002050 | 0.65 | CREBBP (0.46) | HTR1DCREBBP | |
| SCHEMBL6109246 | 0.65 | HTR1D (0.38) | HTR1DHTR1BHTR1A | |
| SCHEMBL32669418 | 0.63 | TTBK1 (0.40) | HTR1DHTR1BMEN1KMT2AHTR2A | |
| SCHEMBL2398840 | 0.60 | AHR (0.52) | HTR1DHTR1BHTR6 | |
| SCHEMBL19776163 | 0.60 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL11437391 | 0.59 | AHR (0.39) | HTR1DHTR1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091953-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4]OXAZEPINO [6, 7-E]INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (publ) (SE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |