Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 13/20 | 0.39 |
| ▸ | HTR1B | P28222 | 8/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092206 | 0.89 | HTR1D (0.47) | MEN1KMT2AHTR1DHTR1BHTR2A | |
| SCHEMBL1536405 | 0.77 | PARP1 (0.39) | MEN1KMT2APARP1 | |
| SCHEMBL4266397 | 0.77 | HTR1D (0.34) | MEN1KMT2AHTR1DHTR1BHTR2A | |
| SCHEMBL3900178 | 0.76 | ADRA2A (0.39) | HTR1AADRA2AADRA2CAHRCREBBP | |
| SCHEMBL2043007 | 0.75 | OXTR (0.38) | HTR1DHTR1BHTR6AHRPARP1 | |
| SCHEMBL2002050 | 0.72 | CREBBP (0.46) | HTR1DAHRCREBBP | |
| SCHEMBL6109246 | 0.71 | HTR1D (0.38) | HTR1DHTR1BHTR1A | |
| SCHEMBL29532058 | 0.70 | TNF (0.35) | MEN1KMT2AHTR1DHTR2AHTR2C | |
| SCHEMBL4829239 | 0.70 | TNF (0.35) | MEN1KMT2AHTR1DHTR2AHTR2C | |
| SCHEMBL19776163 | 0.70 | MEN1 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | disclosed |
| US-8227501-B2 | 1,6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INTERNACIONAL, S.A. (ES) | 2012-07-24 | — | — | US | disclosed |
| CN-102112480-A | 1, 6-dihydro-2H-3-oxa-6-aza-as-indacene compounds | FERRER INT | 2011-06-29 | — | — | CN | disclosed |
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144178-A1 | 1 ,6-DIHYDRO-2H-3-OXA-6-AZA-AS-INDACENE COMPOUNDS | MTNR1A, MTNR1B, ADORA2A | MEN1 1086/4885KMT2A 895/4885HTR1D 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.