Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819298 | 0.79 | OPRD1 (0.33) | OPRD1 | |
| SCHEMBL1627655 | 0.72 | OPRD1 (0.36) | SLC6A2SLC6A4OPRD1OPRM1OPRK1 | |
| SCHEMBL8902843 | 0.71 | SLC6A2 (0.35) | SLC6A2SLC6A4OPRD1OPRM1SIGMAR1 | |
| SCHEMBL1819138 | 0.67 | CHRM2 (0.34) | SLC6A2SLC6A4OPRD1SIGMAR1 | |
| SCHEMBL1820783 | 0.67 | CHRM5 (0.31) | — | |
| SCHEMBL3590885 | 0.67 | SLC6A2 (0.33) | SLC6A2SLC6A4SIGMAR1 | |
| SCHEMBL361322 | 0.66 | MEN1 (0.35) | OPRD1 | |
| SCHEMBL8373305 | 0.66 | OPRD1 (0.33) | OPRD1OPRM1 | |
| SCHEMBL2590668 | 0.64 | OPRD1 (0.43) | SLC6A2SLC6A4OPRD1OPRM1OPRK1 | |
| SCHEMBL3928119 | 0.64 | SIGMAR1 (0.33) | SLC6A2SLC6A4OPRD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |