Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.30 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.30 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.30 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935406 | 0.80 | ADH1B (0.37) | ADH1BADH1CADH1A | |
| SCHEMBL3925051 | 0.78 | KDM4E (0.33) | SIGMAR1ADH1BADH1CADH1A | |
| SCHEMBL3929786 | 0.77 | ALDH1A1 (0.38) | ADH1BADH1CADH1A | |
| SCHEMBL1303959 | 0.76 | ADH1B (0.37) | SIGMAR1CHRM5CHRM3ADH1BADH1C | |
| SCHEMBL928299 | 0.75 | SLC6A2 (0.33) | SIGMAR1SLC6A2SLC6A4OPRD1CHRM5 | |
| SCHEMBL8902843 | 0.72 | SLC6A2 (0.35) | SIGMAR1SLC6A2SLC6A4OPRD1CHRM5 | |
| SCHEMBL4366123 | 0.69 | ADH1B (0.36) | SLC6A2SLC6A4ADH1BADH1CADH1A | |
| SCHEMBL561819 | 0.69 | OPRD1 (0.39) | SIGMAR1SLC6A2SLC6A4OPRD1CHRM5 | |
| SCHEMBL1262907 | 0.69 | SLC6A2 (0.38) | SIGMAR1SLC6A2SLC6A4OPRD1CHRM5 | |
| SCHEMBL9652015 | 0.68 | POLB (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| EP-0078478-B1 | HIGH-FREQUENCY WELDABLE POLYURETHANE FOAMS, AND PROCESS FOR PREPARING THE SAME | BAYER AG (DE) | 1986-05-21 | — | — | EP | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |