Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4271311 | 0.77 | — | — | |
| SCHEMBL108375 | 0.69 | — | — | |
| SCHEMBL10375181 | 0.69 | — | — | |
| SCHEMBL2462887 | 0.69 | — | — | |
| SCHEMBL9948085 | 0.67 | — | — | |
| SCHEMBL6866830 | 0.65 | — | — | |
| SCHEMBL30831806 | 0.63 | FFAR3 (0.47) | TDP1FFAR3ALDH1A1CES2CES1 | |
| SCHEMBL13009507 | 0.63 | FFAR3 (0.47) | TDP1FFAR3ALDH1A1CES2CES1 | |
| SCHEMBL13018317 | 0.63 | — | — | |
| SCHEMBL14196384 | 0.60 | ALDH1A1 (0.53) | TDP1FFAR3ALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608687-B2 | Releasable linkage and compositions containing same | ALZA CORPORATION (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080152702-A1 | Releasable linkage and compositions containing same | ZALIPSKY SAMUEL | 2008-06-26 | — | — | US | disclosed |
| US-7390780-B2 | Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification | ALZA CORPORATION (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1880736-A1 | Releasable linkage and composition containing same | Alza Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7285622-B2 | Releasable linkage and compositions containing same | ALZA CORPORATION (US) | 2007-10-23 | — | — | US | disclosed |
| US-7112337-B2 | Liposome composition for delivery of nucleic acid | ALZA CORPORATION (US) | 2006-09-26 | — | — | US | disclosed |
| EP-1691780-A2 | GENE DELIVERY MEDIATED BY LIPOSOME-DNA COMPLEX WITH CLEAVABLE PEG SURFACE MODIFICATION | ALZA CORPORATION (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20050170508-A1 | Gene delivery mediated by liposome-DNA complex with cleavable PEG surface modification | ALZA CORPORATION | 2005-08-04 | — | — | US | disclosed |
| US-20050123597-A1 | Releasable linkage and compositions containing same | ALZA CORPORATION | 2005-06-09 | — | — | US | disclosed |
| WO-2005051351-A2 | GENE DELIVERY MEDIATED BY LIPOSOME-DNA COMPLEX WITH CLEAVABLE PEG SURFACE MODIFICATION | ALZA CORPORATION (US) | 2005-06-09 | — | — | WO | disclosed |
| US-6849270-B2 | Releasable linkage and compositions containing same | ALZA CORPORATION (US) | 2005-02-01 | — | — | US | disclosed |
| EP-1465599-A1 | LIPOSOME COMPOSITION FOR DELIVERY OF NUCLEIC ACID | ALZA Corporation (US) | 2004-10-13 | — | — | EP | disclosed |
| US-20030211079-A1 | Releasable linkage and compositions containing same | ALZA CORPORATION | 2003-11-13 | — | — | US | disclosed |
| US-6605299-B2 | Hydrophilic polymer covalently and reversibly linked to amine-containing ligand through dithiobenzyl linkage; improves blood circulation time | ALZA CORPORATION | 2003-08-12 | — | — | US | disclosed |
| WO-2003053409-A1 | LIPOSOME COMPOSITION FOR DELIVERY OF NUCLEIC ACID | ALZA CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |
| US-20030031704-A1 | Liposome mixture of a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiological pH, and a lipid joined to a hydrophilic polymer by an aromatic disulfide linkage, associated with a nucleic | ALZA CORPORATION | 2003-02-13 | — | — | US | disclosed |
| US-20020128195-A1 | Releasable linkage and compositions containing same | ALZA CORPORATION | 2002-09-12 | — | — | US | disclosed |
| US-6342244-B1 | HYDROPHILIC POLYMER COVALENTLY YET REVERSIBLY LINKED TO A AMINE-CONTAINING LIGAND THROUGH A DITHIOBENZYL LINKAGE; MODIFICATION OF VARIOUS SUBSTRATES, SUCH AS POLYPEPTIDES, DRUGS AND LIPOSOMES; UPON CLEAVAGE OF THE LINKAGE, THE LIGAND | ALZA CORPORATION | 2002-01-29 | — | — | US | disclosed |
| EP-1173221-A2 | RELEASABLE LINKAGE AND COMPOSITIONS CONTAINING SAME | Alza Corporation (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064483-A2 | RELEASABLE LINKAGE AND COMPOSITIONS CONTAINING SAME | ALZA CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050170508-A1 | Gene delivery mediated by liposome-DNA complex with cleavable PEG surface modification | DNASE1L3, LIPA, DNASE1 | TDP1 1032/4885FFAR3 2387/4885ALDH1A1 3964/4885 |
| US-20030211079-A1 | Releasable linkage and compositions containing same | CD44, ILK, CD69 | TDP1 378/4885FFAR3 3570/4885ALDH1A1 1574/4885 |
| US-20020128195-A1 | Releasable linkage and compositions containing same | CD44, ILK, CD69 | TDP1 378/4885FFAR3 3570/4885ALDH1A1 1574/4885 |
| US-20050123597-A1 | Releasable linkage and compositions containing same | CD44, ILK, CD69 | TDP1 378/4885FFAR3 3570/4885ALDH1A1 1574/4885 |
| US-20030031704-A1 | Liposome mixture of a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiological pH, and a lipid joined to a hydrophilic polymer by an aromatic disulfide linkage, associated with a nucleic | DLST, LIPA, DNAJC10 | TDP1 780/4885FFAR3 1051/4885ALDH1A1 4380/4885 |
| US-20080152702-A1 | Releasable linkage and compositions containing same | CD44, ILK, CD69 | TDP1 378/4885FFAR3 3570/4885ALDH1A1 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.