Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.41 |
| ▸ | PRKCG | P05129 | 4/20 | 0.41 |
| ▸ | PRKCB | P05771 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | PRKCA | P17252 | 4/20 | 0.41 |
| ▸ | PRKCH | P24723 | 4/20 | 0.41 |
| ▸ | PRKCI | P41743 | 4/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.41 |
| ▸ | PRKACA | P17612 | 3/20 | 0.41 |
| ▸ | PRKACG | P22612 | 3/20 | 0.41 |
| ▸ | PRKACB | P22694 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269778 | 0.96 | MEN1 (0.43) | HTR6MEN1KMT2APRKD3PRKCG | |
| SCHEMBL4270134 | 0.82 | HTR6 (0.38) | HTR6KMT2AHTR1AHTR7 | |
| SCHEMBL4269436 | 0.80 | HTR6 (0.54) | HTR6MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4275899 | 0.77 | HTR6 (0.38) | HTR6KMT2AHTR1AHTR7 | |
| SCHEMBL4429023 | 0.73 | HTR6 (0.55) | HTR6MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6643269 | 0.68 | RAPGEF4 (0.52) | HTR6MEN1KMT2APRKD3PRKCG | |
| SCHEMBL4284012 | 0.68 | HTR6 (0.51) | HTR6CYP2D6HTR1AHTR7 | |
| SCHEMBL4431728 | 0.66 | HTR6 (0.49) | HTR6MEN1KMT2ALMNAMAPT | |
| SCHEMBL4273038 | 0.65 | MAPT (0.45) | HTR6MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL1120327 | 0.65 | MAOA (0.59) | CYP2D6LMNAKDM4ECYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070943-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2008-03-20 | — | — | US | claimed |
| US-7291736-B2 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-11-06 | — | — | US | claimed |
| EP-1648891-A1 | SULFONYLDIHYDROIMID- AZOPYRIDINONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005010003-A1 | SULFONYLDIHYDROIMID- AZOPYRIDINONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-02-03 | — | — | WO | claimed |
| US-20050020596-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-01-27 | — | — | US | claimed |
| US-7608717-B2 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080070943-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2008-03-20 | — | — | US | disclosed |
| US-7291736-B2 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1648891-A1 | SULFONYLDIHYDROIMID- AZOPYRIDINONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005010003-A1 | SULFONYLDIHYDROIMID- AZOPYRIDINONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20050020596-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070943-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | HTR6 1/4885MEN1 1770/4885KMT2A 1654/4885 |
| US-20050020596-A1 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | HTR6 1/4885MEN1 1770/4885KMT2A 1654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.