Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272531 | 0.86 | MTNR1A (0.44) | MTNR1AMTNR1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4276569 | 0.84 | LMNA (0.54) | MTNR1AMTNR1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4272576 | 0.81 | MTNR1A (0.41) | MTNR1AMTNR1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL715593 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHR | |
| SCHEMBL4268400 | 0.80 | CYP4F2 (0.50) | MTNR1AMTNR1B | |
| SCHEMBL4268391 | 0.79 | CYP4F2 (0.54) | MTNR1AMTNR1B | |
| SCHEMBL4568918 | 0.76 | KMT2A (0.57) | KDM4EALDH1A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL5825053 | 0.76 | TSHR (0.60) | MTNR1AMTNR1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2205073 | 0.76 | TAAR1 (0.55) | ALDH1A1TSHR | |
| SCHEMBL29818959 | 0.76 | TAAR1 (0.55) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |