Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737221 | 0.87 | PLA2G4B (0.56) | LMNACYP3A4ACHEMAPK1L3MBTL1 | |
| SCHEMBL1196100 | 0.85 | PLA2G4B (0.58) | LMNACYP3A4KMT2ATSHR | |
| SCHEMBL4272535 | 0.85 | LMNA (0.53) | LMNACYP3A4ACHEMTNR1AMTNR1B | |
| SCHEMBL9692573 | 0.85 | KMT2A (0.61) | LMNACYP3A4ACHEMTNR1AMTNR1B | |
| SCHEMBL4276565 | 0.84 | MTNR1A (0.46) | LMNAMTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL715593 | 0.84 | ALDH1A1 (0.54) | ALDH1A1TSHR | |
| SCHEMBL4576561 | 0.83 | LMNA (0.54) | LMNACYP3A4ACHEMTNR1AMTNR1B | |
| Ammonia Solution, Strong SCHEMBL9172111 | 0.83 | PLA2G4B (0.59) | LMNACYP3A4MTNR1AKMT2ATSHR | |
| SCHEMBL249305 | 0.82 | LMNA (0.76) | LMNACYP3A4ACHEKDM4EALDH1A1 | |
| SCHEMBL17028900 | 0.82 | LMNA (0.76) | LMNACYP3A4ACHEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |