Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9689543 | 0.98 | HTR6 (0.39) | HTR6CA1CA2KDM4EMEN1 | |
| SCHEMBL10379108 | 0.81 | HTR6 (0.41) | HTR6CA1CA2HRH3 | |
| Hydrochloric Acid SCHEMBL10570274 | 0.80 | HTR6 (0.40) | HTR6CA1CA2L3MBTL1HRH3 | |
| SCHEMBL10378092 | 0.78 | HTR6 (0.33) | HTR6CA1CA2 | |
| SCHEMBL9688270 | 0.77 | TP53 (0.39) | KDM4EMEN1KMT2AHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10379118 | 0.77 | HTR6 (0.33) | HTR6CA1CA2 | |
| SCHEMBL253563 | 0.77 | PTGDR2 (0.49) | CA1CA2KDM4EMEN1KMT2A | |
| SCHEMBL9689143 | 0.76 | ESRRG (0.42) | HTR6KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5441635 | 0.75 | SIGMAR1 (0.43) | HTR6CA1CA2KDM4EMEN1 | |
| SCHEMBL9688384 | 0.74 | CA1 (0.33) | HTR6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608626-B2 | Substituted indolizines and derivatives as CNS agents | WYETH (US) | 2009-10-27 | — | — | US | claimed |
| US-20060094752-A1 | Substituted indolizines and derivatives as CNS agents | WYETH (US) | 2006-05-04 | — | — | US | claimed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | claimed |
| US-7608626-B2 | Substituted indolizines and derivatives as CNS agents | WYETH (US) | 2009-10-27 | — | — | US | disclosed |
| EP-1807427-A2 | SUBSTITUTED INDOLIZINES AND DERIVATIVES AS CNS AGENTS | Wyeth (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006050007-A2 | SUBSTITUTED INDOLIZINES AND DERIVATIVES AS CNS AGENTS | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060094752-A1 | Substituted indolizines and derivatives as CNS agents | WYETH (US) | 2006-05-04 | — | — | US | disclosed |
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4968699-A | CENTRAL NERVOUS SYSTEM; ANTIISCHEMIC AND ANTIHYPOXIC AGENTS; ACTIVE AGAINST CEREBRAL OXYGEN DEFICIENCY | BEECHAM-WUELFING GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094752-A1 | Substituted indolizines and derivatives as CNS agents | HTR2C, HTR3A, HTR1A | HTR6 21/4885CA1 3419/4885CA2 3441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.