SCHEMBL4278065

SCHEMBL4278065

O=[N+]([O-])c1ccc(N=Nc2ccccc2O)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 8/20 0.68
KMT2A Q03164 8/20 0.68
MAPT P10636 7/20 0.68
ALDH1A1 P00352 5/20 0.68
HTT P42858 3/20 0.68
LMNA P02545 2/20 0.68
NPSR1 Q6W5P4 2/20 0.68
POLB P06746 2/20 0.68
SMN1; SMN2 Q16637 4/20 0.54
TDP1 Q9NUW8 2/20 0.54
NPC1 O15118 4/20 0.53
KDM4E B2RXH2 1/20 0.53
RAB9A P51151 4/20 0.51
MAPK1 P28482 3/20 0.51
HSP90AA1 P07900 2/20 0.51
RECQL P46063 1/20 0.51
CASP3 P42574 2/20 0.50
SENP8 Q96LD8 2/20 0.50
SENP7 Q9BQF6 2/20 0.50
SENP6 Q9GZR1 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4278053 1.00 MEN1 (0.68) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL4278058 1.00 MEN1 (0.68) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL8827154 0.85 MAPT (0.89) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL8827131 0.85 MAPT (0.89) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL8556068 0.83 MEN1 (0.57) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL1276291 0.83 ALDH1A1 (0.68) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL31307193 0.83 MEN1 (0.57) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL1276292 0.83 ALDH1A1 (0.68) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL28002467 0.83 MEN1 (0.59) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL10898315 0.83 MEN1 (0.57) MEN1KMT2AMAPTALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090258429-A1 Colorimetric detection of cyanide with a chromogenic oxazine MIAMI, THE UNIVERSITY OF 2009-10-15 US claimed
WO-2007028080-A1 COLORIMETRIC DETECTION OF CYANIDE WITH A CHROMOGENIC OXAZINE THE UNIVERSITY OF MIAMI (US) 2007-03-08 WO claimed
WO-2026082575-A1 SYNTHESIS OF STABLE ISOTOPE LABELED VERSIONS OF N-(4-HYDROXYPHENYL)ACETAMID ROCHE DIAGNOSTICS GMBH (DE) 2026-04-23 WO disclosed
US-20220404323-A1 INDICATOR MATERIAL COMPRISING A POLYMERIC GEL CARRIER AND POLYMERIC INDICATOR MOOW.FARM KFT. (HU) 2022-12-22 US disclosed
US-8198436-B2 Colorimetric detection of cyanide with a chromogenic oxazine THE UNIVERSITY OF MIAMI (US) 2012-06-12 US disclosed
US-20090258429-A1 Colorimetric detection of cyanide with a chromogenic oxazine MIAMI, THE UNIVERSITY OF 2009-10-15 US disclosed
US-20080305047-A1 Chemosensors Based on Quantum Dots and Oxazine Compounds NATIONAL SCIENCE FOUNDATION 2008-12-11 US disclosed
WO-2008018894-A2 CHEMOSENSORS BASED ON QUANTUM DOTS AND OXAZINE COMPOUNDS THE UNIVERSITY OF MIAMI (US) 2008-02-14 WO disclosed
WO-2007028080-A1 COLORIMETRIC DETECTION OF CYANIDE WITH A CHROMOGENIC OXAZINE THE UNIVERSITY OF MIAMI (US) 2007-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080305047-A1 Chemosensors Based on Quantum Dots and Oxazine Compounds OR51E2, CDYL, CDYL2 MEN1 4457/4885KMT2A 4460/4885MAPT 2426/4885
US-20090258429-A1 Colorimetric detection of cyanide with a chromogenic oxazine CBR3, CBR1, CYCS MEN1 4062/4885KMT2A 3788/4885MAPT 4305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.