Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29673233 | 0.79 | DRD2 (0.55) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL773532 | 0.75 | PNMT (0.53) | DRD2 | |
| SCHEMBL772708 | 0.75 | ASIC3 (0.53) | DRD2PLAUF2 | |
| SCHEMBL29530477 | 0.74 | KDM4E (0.81) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL2638095 | 0.74 | KDM4E (0.81) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL2610325 | 0.72 | MAPT (0.58) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL698487 | 0.72 | KDM4E (0.78) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL29779540 | 0.72 | KDM4E (0.58) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL4051485 | 0.72 | KDM4E (0.58) | DRD2DRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL18175179 | 0.72 | DRD2 (0.55) | DRD2DRD4MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151621-A1 | SUBSTITUTED (1, 2, 4-0XADIAZ0L-3-YL) INDOLIN-1-YL CARBOXYLIC ACID DERIVATIVES USEFUL AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |