Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282042 | 0.96 | MTNR1A (0.48) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4268391 | 0.87 | CYP4F2 (0.54) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL1635492 | 0.86 | PPARA (0.63) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4268400 | 0.85 | CYP4F2 (0.50) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4279635 | 0.85 | CYP3A4 (0.50) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4282046 | 0.81 | CYP3A4 (0.51) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4270867 | 0.80 | MTNR1A (0.42) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4272531 | 0.79 | MTNR1A (0.44) | MTNR1AMTNR1B | |
| SCHEMBL4278418 | 0.79 | MTNR1A (0.43) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL20597733 | 0.79 | LOXL2 (0.50) | MTNR1AMTNR1BACHETAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |