Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 5/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 5/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 5/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 5/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.35 |
| ▸ | CACNG7 | P62955 | 5/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.35 |
| ▸ | CACNG1 | Q06432 | 5/20 | 0.35 |
| ▸ | CACNB2 | Q08289 | 5/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27415464 | 0.86 | KDM4E (0.46) | KDM4EGRNSORT1HRH3CACNB4 | |
| SCHEMBL1853083 | 0.83 | GPR119 (0.52) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL21004595 | 0.80 | FPR2 (0.37) | HRH3CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL4282720 | 0.76 | GPR119 (0.45) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL21604151 | 0.72 | CCNE1 (0.39) | KDM4ECACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL26926850 | 0.72 | CACNB4 (0.51) | KDM4ECACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL1850724 | 0.69 | GPR119 (0.52) | KDM4ECACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL2516746 | 0.69 | KDM4E (0.53) | KDM4EGRNSORT1GSK3BCCNE1 | |
| SCHEMBL21604042 | 0.69 | GRN (0.54) | KDM4EGRNSORT1 | |
| SCHEMBL21597708 | 0.69 | KDM4E (0.43) | KDM4EGRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |