Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 0.54 |
| ▸ | PPARA | Q07869 | 15/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071239 | 0.86 | NR4A2 (0.61) | PPARGPPARA | |
| SCHEMBL27700293 | 0.86 | SLC6A4 (0.48) | PPARGPPARASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4283538 | 0.82 | SLC6A2 (0.47) | PPARGPPARASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4795941 | 0.82 | SLC7A5 (0.60) | SLC6A2 | |
| SCHEMBL27807869 | 0.82 | MME (0.51) | PPARGPPARA | |
| SCHEMBL4826192 | 0.81 | CYP1A2 (0.61) | — | |
| SCHEMBL4316458 | 0.81 | CYP1A2 (0.61) | — | |
| SCHEMBL6712771 | 0.81 | PPARG (0.59) | PPARGPPARASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL490844 | 0.81 | CYP1A2 (0.61) | — | |
| SCHEMBL20766143 | 0.80 | CPA1 (0.51) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113929618-B | Oxo-pyridine amide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-113912586-B | Oxopyridine amide derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-113929618-A | Oxopyridine amide derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-113912586-A | Oxopyridine amide derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2022-01-11 | — | — | CN | disclosed |
| EP-3486242-B1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-12-08 | — | — | EP | disclosed |
| CN-108495850-B | Oxopyridine amide derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2021-11-26 | — | — | CN | disclosed |
| US-11084808-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-08-10 | — | — | US | disclosed |
| US-20200199115-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2020-06-25 | — | — | US | disclosed |
| US-10633375-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | Jinagsu Hengrui Medicine Co., Ltd (CN) | 2020-04-28 | — | — | US | disclosed |
| US-20190185464-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-06-20 | — | — | US | disclosed |
| EP-3486242-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-05-22 | — | — | EP | disclosed |
| CN-101967129-B | Preparation method of 4-aryl-1H-1, 2, 3-triazole | UNIV TONGJI | 2012-02-29 | — | — | CN | disclosed |
| CN-101967129-A | Preparation method of 4-aryl-1H-1, 2, 3-triazole | UNIV TONGJI | 2011-02-09 | — | — | CN | disclosed |
| EP-1173427-B1 | HYDROXAMIC ACID DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO (JP) | 2006-04-05 | — | — | EP | disclosed |
| CN-1658871-A | Amide derivatives as GK activators | NOVO NORDISK AS (DK) | 2005-08-24 | — | — | CN | disclosed |
| US-6713477-B1 | 1,4-BENZTHIAZINES OR BENZOXAZINES; MATRIX METALLOPROTEINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-30 | — | — | US | disclosed |
| EP-1173427-A1 | HYDROXAMIC ACID DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063197-A1 | HYDROXAMIC ACID DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633375-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | F11, F2, F7 | PPARG 3318/4885PPARA 3176/4885SLC6A4 2756/4885 |
| US-20200199115-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | F11, F2, F7 | PPARG 3622/4885PPARA 3333/4885SLC6A4 2836/4885 |
| US-20190185464-A1 | OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | F11, F2, F7 | PPARG 3318/4885PPARA 3176/4885SLC6A4 2756/4885 |
| US-11084808-B2 | Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof | F11, F2, F7 | PPARG 3318/4885PPARA 3176/4885SLC6A4 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.