Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 12/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.50 |
| ▸ | HTR3B | O95264 | 6/20 | 0.50 |
| ▸ | HTR3A | P46098 | 6/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14092967 | 0.91 | ADRB1 (0.83) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL15315532 | 0.89 | ADRB1 (0.54) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL12187539 | 0.88 | ADRB1 (0.54) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL24123744 | 0.88 | ADRB1 (0.68) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL24123762 | 0.88 | ADRB1 (0.57) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL25678183 | 0.85 | ADRB1 (0.73) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL12187540 | 0.82 | ADRB1 (0.47) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL270532 | 0.82 | HTR3E (0.71) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL14616906 | 0.80 | CHRNB2 (0.58) | ADRB1CHRNB2CHRNA4 | |
| SCHEMBL1914919 | 0.80 | ADRB1 (1.00) | ADRB1CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132454-A1 | DI-T-BUTYLPHENYL PIPERAZINES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-11-05 | — | — | WO | disclosed |
| US-20090270413-A1 | DI-T-BUTYLPHENYL PIPERAZINES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2009-10-29 | — | — | US | disclosed |
| US-20090270413-A1 | DI-T-BUTYLPHENYL PIPERAZINES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2009-10-29 | — | — | US | disclosed |
| US-20090270413-A1 | DI-T-BUTYLPHENYL PIPERAZINES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270413-A1 | DI-T-BUTYLPHENYL PIPERAZINES AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1C, CACNA1I | ADRB1 229/4885CHRM2 1403/4885CHRM4 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.