SCHEMBL4287423

SCHEMBL4287423

COc1ccc(C(=O)c2c(O)cc(CO)cc2Br)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.50
LMNA P02545 1/20 0.50
MAPT P10636 1/20 0.50
MAPK1 P28482 1/20 0.50
RAB9A P51151 1/20 0.50
KMT2A Q03164 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
SLC22A12 Q96S37 3/20 0.46
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46
TUBB3 Q13509 1/20 0.46
TUBB2A Q13885 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4281069 0.84 CYP3A4 (0.56) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL4288666 0.84 KMT2A (0.46) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL4287006 0.83 NFKB1 (0.46) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL4288308 0.83 HPGD (0.50) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL4292221 0.81 MEN1 (0.54) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL5940583 0.75 RAB9A (0.61) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL14275249 0.72 CES2 (0.73) MAPTRAB9ACES2CES1ALDH1A1
SCHEMBL12221631 0.72 LMNA (0.52) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL5622859 0.71 NFKB1 (0.62) MEN1LMNAMAPTMAPK1RAB9A
SCHEMBL20157412 0.70 NPC1 (0.54) MEN1LMNAMAPTMAPK1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 MEN1 3776/4885LMNA 3975/4885MAPT 2884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.