SCHEMBL4288353

SCHEMBL4288353

CCCOc1ccc(C(=O)C2=C(F)CC(C)CC2=O)cc1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.44
PLK1 P53350 1/20 0.44
HPGD P15428 3/20 0.43
LMNA P02545 4/20 0.40
HTT P42858 2/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
KMT2A Q03164 1/20 0.39
PTPN7 P35236 1/20 0.39
DUSP3 P51452 1/20 0.39
CYP19A1 P11511 1/20 0.39
MAPK1 P28482 1/20 0.39
MAPT P10636 3/20 0.39
THRB P10828 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4288581 0.90 KMT2A (0.46) L3MBTL1PLK1HPGDLMNAALDH1A1
SCHEMBL4287147 0.83 LMNA (0.44) HPGDLMNAALDH1A1KMT2AMAPK1
SCHEMBL4287440 0.76 KMT2A (0.47) L3MBTL1PLK1HPGDLMNAHTT
SCHEMBL4288403 0.75 NPSR1 (0.46) L3MBTL1PLK1HPGDLMNAALDH1A1
SCHEMBL6341040 0.73 L3MBTL1 (0.68) L3MBTL1PLK1LMNAKMT2ACYP19A1
SCHEMBL4288059 0.73 L3MBTL1 (0.49) L3MBTL1PLK1HPGDLMNAALDH1A1
SCHEMBL11578668 0.69 KMT2A (0.67) L3MBTL1PLK1HPGDLMNAALDH1A1
SCHEMBL4279762 0.69 LMNA (0.45) HPGDLMNAALDH1A1KMT2AMAPK1
SCHEMBL4284546 0.69 LMNA (0.45) HPGDLMNAALDH1A1KMT2AMAPK1
SCHEMBL13845292 0.68 LTA4H (0.68) L3MBTL1PLK1HPGDLMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 L3MBTL1 2087/4885PLK1 4871/4885HPGD 2655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.