SCHEMBL4288581

SCHEMBL4288581

CCOc1ccc(C(=O)C2=C(F)CC(C)CC2=O)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
PARP10 Q53GL7 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
LMNA P02545 1/20 0.43
MAPK1 P28482 1/20 0.43
HPGD P15428 4/20 0.42
KDM4E B2RXH2 4/20 0.42
ALDH1A1 P00352 4/20 0.42
NPC1 O15118 3/20 0.42
HSD17B10 Q99714 2/20 0.42
MAPT P10636 2/20 0.42
ALOX15 P16050 2/20 0.42
RAB9A P51151 2/20 0.42
RECQL P46063 1/20 0.42
TSHR P16473 1/20 0.42
PLK1 P53350 1/20 0.41
MAOB P27338 1/20 0.40
PLA2G4B P0C869 1/20 0.40
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4288353 0.90 L3MBTL1 (0.44) KMT2AL3MBTL1LMNAMAPK1HPGD
SCHEMBL4287440 0.86 KMT2A (0.47) KMT2ANPSR1PARP10L3MBTL1LMNA
SCHEMBL4287147 0.85 LMNA (0.44) KMT2ANPSR1PARP10LMNAMAPK1
SCHEMBL4288403 0.85 NPSR1 (0.46) KMT2ANPSR1PARP10L3MBTL1LMNA
SCHEMBL4282979 0.82 KMT2A (0.44) KMT2APARP10LMNAHPGDKDM4E
SCHEMBL845348 0.72 NPSR1 (0.79) KMT2ANPSR1PARP10L3MBTL1LMNA
SCHEMBL4282991 0.72 POLB (0.45) KMT2APARP10MAPK1HPGDKDM4E
SCHEMBL4280973 0.71 ALDH1A1 (0.43) KMT2AL3MBTL1LMNAHPGDKDM4E
SCHEMBL11042318 0.71 KMT2A (0.67) KMT2ANPSR1PARP10L3MBTL1LMNA
SCHEMBL4279762 0.70 LMNA (0.45) KMT2ANPSR1PARP10LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 KMT2A 1397/4885NPSR1 1569/4885PARP10 2557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.