Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 1.00 |
| ▸ | PRSS2 | P07478 | 1/20 | 1.00 |
| ▸ | PRSS3 | P35030 | 1/20 | 1.00 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.68 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.66 |
| ▸ | F2 | P00734 | 2/20 | 0.66 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.66 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.66 |
| ▸ | PLAU | P00749 | 1/20 | 0.66 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.66 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.66 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.66 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.66 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.66 |
| ▸ | F10 | P00742 | 1/20 | 0.66 |
| ▸ | PLG | P00747 | 1/20 | 0.66 |
| ▸ | S100B | P04271 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11613449 | 0.98 | PRSS1 (0.96) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL10492891 | 0.87 | PRSS1 (0.75) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL23902238 | 0.85 | PRSS1 (0.79) | PRSS1PRSS2PRSS3F2ST14 | |
| Hydrochloric Acid SCHEMBL11151164 | 0.85 | PRSS1 (0.73) | PRSS1PRSS2PRSS3TMPRSS2F2 | |
| SCHEMBL9647355 | 0.84 | PRSS1 (0.78) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL9650651 | 0.84 | PRSS1 (0.81) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL12348319 | 0.83 | PRSS1 (0.76) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL6486178 | 0.83 | PRSS1 (0.70) | PRSS1PRSS2PRSS3PARP10 | |
| Hydrochloric Acid SCHEMBL11182186 | 0.82 | PRSS1 (0.82) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| Hydrochloric Acid SCHEMBL11614015 | 0.82 | PRSS1 (0.79) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345894-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | Chen, Kuenfeng (TW) | 2018-07-11 | — | — | EP | disclosed |
| US-20170298057-A1 | DEUTERATED O-SULFATED BETA LACTAM HYDROXAMIC ACIDS AND DEUTERATED N- SULFATED BETA LACTAMS | ARIXA PHARMACEUTICALS, INC. | 2017-10-19 | — | — | US | disclosed |
| WO-2017180794-A1 | DEUTERATED O-SULFATED BETA-LACTAM HYDROXAMIC ACIDS AND DEUTERATED N-SULFATED BETA-LACTAMS | SKYLINE ANTIINFECTIVES, INC. (US) | 2017-10-19 | — | — | WO | disclosed |
| US-20130059869-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | HYDRA BIOSCIENCES, INC. | 2013-03-07 | — | — | US | disclosed |
| US-20120022030-A1 | Tetracyclic Lactame Derivatives | NOVARTIS AG | 2012-01-26 | — | — | US | disclosed |
| US-7838674-B2 | 2-(1-amino-cyclobutylmethyl)-8-(4-methoxy-phenyl)-4,5-dihydro-1 H-1,7,9-triazacyclopenta[a]naph-thalene-3-carboxylic acid lactame; useful especially as inhibitors of mitogen-activated protein kinase-activated protein kinase-2 (MK2 or MAPKAP kinase-2 | NOVARTIS AG (CH) | 2010-11-23 | — | — | US | disclosed |
| US-7825154-B2 | Small molecule inhibitors of botulinum neurotoxins | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2010-11-02 | — | — | US | disclosed |
| EP-2178874-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS | Novartis Ag (CH) | 2010-04-28 | — | — | EP | disclosed |
| EP-1383731-B1 | BIARYL COMPOUNDS AS SERINE PROTEASE INHIBITORS | BIOCRYST PHARM INC (US) | 2009-08-05 | — | — | EP | disclosed |
| US-20090098218-A1 | Tetracyclic Lactame Derivatives | NOVARTIS AG | 2009-04-16 | — | — | US | disclosed |
| WO-2009010488-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS | NOVARTIS AG (CH) | 2009-01-22 | — | — | WO | disclosed |
| US-20090012107-A1 | Antiviral Compounds and Methods of Using Thereof | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2009-01-08 | — | — | US | disclosed |
| US-5112523-A | High clearing point for liquid crystal displays | CHISSO CORPORATION (JP) | 1992-05-12 | — | — | US | disclosed |
| US-4874546-A | LIQUID CRYSTALS | CHISSO CORPORATION (JP) | 1989-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298057-A1 | DEUTERATED O-SULFATED BETA LACTAM HYDROXAMIC ACIDS AND DEUTERATED N- SULFATED BETA LACTAMS | DDOST, LBR, STS | PRSS1 295/4885PRSS2 255/4885PRSS3 270/4885 |
| US-20090012107-A1 | Antiviral Compounds and Methods of Using Thereof | ZC3HAV1, MAVS, ZC3HAV1L | PRSS1 548/4885PRSS2 558/4885PRSS3 568/4885 |
| US-20120022030-A1 | Tetracyclic Lactame Derivatives | TNF, RPS6KB2, RPS6KA2 | PRSS1 2054/4885PRSS2 866/4885PRSS3 2920/4885 |
| US-20130059869-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | PRSS1 2883/4885PRSS2 2422/4885PRSS3 2006/4885 |
| US-20090098218-A1 | Tetracyclic Lactame Derivatives | TNF, RPS6KB2, RPS6KA2 | PRSS1 2054/4885PRSS2 866/4885PRSS3 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.