Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24865322 | 0.75 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2ALDH1A1TP53LMNA | |
| SCHEMBL25542682 | 0.73 | KMT2A (0.43) | SMN1; SMN2ALDH1A1TP53LMNAOPRM1 | |
| SCHEMBL1232993 | 0.73 | KMT2A (0.43) | SMN1; SMN2ALDH1A1TP53LMNAOPRM1 | |
| SCHEMBL5068716 | 0.72 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1TP53LMNAOPRM1 | |
| Hydrochloric Acid SCHEMBL6557848 | 0.70 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1TP53LMNAOPRM1 | |
| SCHEMBL25571365 | 0.69 | OPRM1 (0.39) | MAPTSMN1; SMN2ALDH1A1TP53OPRM1 | |
| SCHEMBL11051641 | 0.68 | MAPT (0.40) | MAPTSMN1; SMN2ALDH1A1TP53LMNA | |
| SCHEMBL2069363 | 0.67 | OPRM1 (0.56) | SMN1; SMN2ALDH1A1TP53LMNAOPRM1 | |
| SCHEMBL2338585 | 0.67 | MAPT (0.53) | MAPTSMN1; SMN2LMNAOPRM1GRIN2D | |
| SCHEMBL4674910 | 0.67 | ALDH1A1 (0.53) | MAPTSMN1; SMN2ALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | MAPT 2159/4885SMN1; SMN2 2937/4885ALDH1A1 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.