Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.45 |
| ▸ | WNT1 | P04628 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4279816 | 0.99 | PTGER1 (0.46) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| SCHEMBL4285351 | 0.88 | MAPT (0.46) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| SCHEMBL4276192 | 0.87 | HPGD (0.58) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL4287368 | 0.87 | MAPT (0.45) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| SCHEMBL4284197 | 0.87 | MAPT (0.45) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL4287252 | 0.86 | HPGD (0.57) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| SCHEMBL4288574 | 0.83 | SCD (0.48) | ROCK2 | |
| SCHEMBL3737875 | 0.82 | L3MBTL1 (0.59) | SLC2A1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4277759 | 0.82 | PTGER1 (0.48) | PTGER1SLC2A1WNT1GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL3734681 | 0.81 | L3MBTL1 (0.58) | PTGER1SLC2A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | claimed |
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |