Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.45 |
| ▸ | S100A10 | P60903 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 9/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 9/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290719 | 1.00 | KDM4E (0.46) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4303021 | 0.93 | KDM4E (0.46) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4303017 | 0.93 | KDM4E (0.46) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4300191 | 0.91 | KDM4E (0.43) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4300196 | 0.91 | KDM4E (0.43) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4300189 | 0.91 | KDM4E (0.43) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4293563 | 0.86 | CYP1A2 (0.46) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4293567 | 0.86 | CYP1A2 (0.46) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4300011 | 0.83 | KDM4E (0.47) | KDM4ERXFP1ANXA2S100A10MEN1 | |
| SCHEMBL4300014 | 0.83 | KDM4E (0.47) | KDM4ERXFP1ANXA2S100A10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278345-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2012-10-02 | — | — | US | claimed |
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-10-29 | — | — | US | claimed |
| US-8278345-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2012-10-02 | — | — | US | disclosed |
| CN-1639113-B | Method for producing 2-chloromethylphenyl acetic acid derivatives | BASF AG | 2011-06-01 | — | — | CN | disclosed |
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-10-29 | — | — | US | disclosed |
| US-20090177005-A1 | Method For Producing 2-(chloromethyl)penylacetic acid derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2009-07-09 | — | — | US | disclosed |
| US-7488840-B2 | Method for producing 2-chloromethylphenyl acetic acid derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2009-02-10 | — | — | US | disclosed |
| CN-1639113-A | Method for producing 2-chloromethylphenyl acetic acid derivatives | BASF AG (DE) | 2005-07-13 | — | — | CN | disclosed |
| US-20050113597-A1 | Method for producing 2-chloromethylphenyl acetic acid derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269301-A1 | Novel Inhibitors of Glutaminyl Cyclase | GLS, GLS2, GLUL | KDM4E 2532/4885RXFP1 1183/4885ANXA2 4727/4885 |
| US-20050113597-A1 | Method for producing 2-chloromethylphenyl acetic acid derivatives | CA6, CA4, C5 | KDM4E 1789/4885RXFP1 3972/4885ANXA2 751/4885 |
| US-20090177005-A1 | Method For Producing 2-(chloromethyl)penylacetic acid derivatives | C5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PCCA | KDM4E 1459/4885RXFP1 4471/4885ANXA2 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.