Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Lysyl-Tyrosyl-Lysine Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 5/20 | 0.61 |
| ▸ | NPY1R | P25929 | 4/20 | 0.61 |
| ▸ | NPY2R | P49146 | 3/20 | 0.61 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.57 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.54 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.53 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.53 |
| ▸ | GNPAT | O15228 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysyl-Tyrosyl-Lysine Acetate SCHEMBL6275111 | 0.97 | NPY4R (0.62) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| Lysyl-Tyrosyl-Lysine Acetate SCHEMBL6275116 | 0.97 | NPY4R (0.62) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| SCHEMBL27942027 | 0.97 | NPY4R (0.62) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| SCHEMBL30851358 | 0.95 | NPY4R (0.63) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| Acetic Acid SCHEMBL28326516 | 0.94 | NPY4R (0.59) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| Acetic Acid SCHEMBL20489334 | 0.94 | NPY4R (0.59) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| SCHEMBL30523264 | 0.94 | LNPEP (0.63) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| SCHEMBL29577087 | 0.93 | NPY4R (0.59) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| SCHEMBL29576811 | 0.93 | NPY4R (0.59) | NPY4RNPY1RNPY2RLNPEPERAP2 | |
| SCHEMBL30931517 | 0.93 | LNPEP (0.62) | NPY4RNPY1RNPY2RLNPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-06-04 | — | — | US | disclosed |
| WO-2008156654-A2 | CYTOSKELETON MODULATORS FOR TREATING METABOLIC DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PC, PCK2, CS | NPY4R 1672/4885NPY1R 2267/4885NPY2R 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.