SCHEMBL4291802

SCHEMBL4291802

Nc1nc(F)nc2nc[nH]c12.O=P(O)(O)OC[C@H]1OC(O)[C@@H](O)[C@@H]1O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA5A P35218 1/20 0.52
NT5E P21589 1/20 0.43
FBP1 P09467 3/20 0.42
HPRT1 P00492 1/20 0.42
TRPM2 O94759 2/20 0.41
TAS1R3 Q7RTX0 2/20 0.41
TAS1R1 Q7RTX1 2/20 0.41
DNPH1 O43598 1/20 0.41
PRKAB2 O43741 1/20 0.41
LDHA P00338 1/20 0.41
ADRB2 P07550 1/20 0.41
SRC P12931 1/20 0.41
ADORA1 P30542 1/20 0.41
P2RY2 P41231 1/20 0.41
P2RY1 P47900 1/20 0.41
PRKAG1 P54619 1/20 0.41
PRKAA2 P54646 1/20 0.41
PDE4D Q08499 1/20 0.41
KCNH2 Q12809 1/20 0.41
PRKAA1 Q13131 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenine SCHEMBL7996359 0.85 TRPM2 (0.49) CA5AFBP1HPRT1TRPM2TAS1R3
Adenine SCHEMBL11136514 0.85 TRPM2 (0.49) CA5AFBP1HPRT1TRPM2TAS1R3
Adenine SCHEMBL3921122 0.85 TRPM2 (0.49) CA5AFBP1HPRT1TRPM2TAS1R3
Ribose (Furanose) SCHEMBL4284369 0.84 HIF1A (0.46) NT5EADORA1SMN1; SMN2
SCHEMBL717431 0.83 CA5A (0.39) CA5AFBP1HPRT1TRPM2TAS1R3
Guanine SCHEMBL9861048 0.83 PNP (0.52) NT5EFBP1HPRT1UMPS
SCHEMBL6305780 0.81 CA5A (0.43) CA5ANT5EFBP1HPRT1TAS1R3
Mercaptopurine Anhydrous SCHEMBL8627151 0.77 FBP1 (0.44) FBP1HPRT1TRPM2TAS1R3TAS1R1
SCHEMBL15167310 0.77 TRPM2 (0.41) TRPM2P2RY1P2RY11MACROD2SIRT6
SCHEMBL15166956 0.76 TRPM2 (0.43) TRPM2P2RY1P2RY11MACROD2SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11364043-B2 Methods and devices for endovascular therapy CARDIOPROLIFIC INC. (US) 2022-06-21 US disclosed
US-11116528-B2 Methods and devices for endovascular therapy CARDIOPROLIFIC, INC. (US) 2021-09-14 US disclosed
US-11039845-B2 Methods and devices for endovascular therapy CARDIOPROLIFIC INC. (US) 2021-06-22 US disclosed
US-20170202949-A1 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE PROVIDENCE HEALTH & SERVICES - OREGON (US) 2017-07-20 US disclosed
US-20160367274-A1 METHODS AND DEVICES FOR ENDOVASCULAR THERAPY CARDIOPROLIFIC INC (US) 2016-12-22 US disclosed
US-20160367275-A1 METHODS AND DEVICES FOR ENDOVASCULAR THERAPY CARDIOPROLIFIC INC (US) 2016-12-22 US disclosed
US-20160270806-A1 METHODS AND DEVICES FOR ENDOVASCULAR THERAPY CARDIOPROLIFIC INC (US) 2016-09-22 US disclosed
US-9375223-B2 Methods and devices for endovascular therapy CARDIOPROLIFIC INC. (US) 2016-06-28 US disclosed
US-20140186292-A1 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE PROVIDENCE HEALTH & SERVICES - OREGON (US) 2014-07-03 US disclosed
US-20140142494-A1 METHODS AND DEVICES FOR ENDOVASCULAR THERAPY CARDIOPROLIFIC INC. 2014-05-22 US disclosed
US-20130345617-A1 METHODS AND DEVICES FOR REMOVAL OF TISSUE, BLOOD CLOTS AND LIQUIDS FROM THE PATIENT CARDIOPROLIFIC INC. 2013-12-26 US disclosed
EP-1912672-B1 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE PROVIDENCE HEALTH SYSTEM (US) 2013-09-04 EP disclosed
US-20130023897-A1 Devices and Methods for Endovascular Therapies CARDIOPROLIFIC INC. 2013-01-24 US disclosed
US-20120215099-A1 Methods and Apparatus for Endovascular Ultrasound Delivery CARDIOPROLIFIC INC. 2012-08-23 US disclosed
WO-2012026982-A1 ULTRASOUND-ENHANCED STENOSIS THERAPY WALLACE MICHAEL P (US) 2012-03-01 WO disclosed
US-20090220530-A1 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE PROVIDENCE HEALTH SYSTEM 2009-09-03 US disclosed
EP-1912672-A2 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE Providence Health System (US) 2008-04-23 EP disclosed
WO-2007016340-A2 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE PROVIDENCE HEALTH SYSTEM (US) 2007-02-08 WO disclosed
US-20010039952-A1 ULTRASOUND ENHANCED CHEMOTHERAPY WALTER A. HACKER, PH. D 2001-11-15 US disclosed
US-6308714-B1 Ultrasound enhanced chemotherapy CORAJE, INC. 2001-10-30 US disclosed