Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mercaptopurine Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 3/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | DNPH1 | O43598 | 3/20 | 0.40 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL7996359 | 0.87 | TRPM2 (0.49) | FBP1HPRT1DNPH1TRPM2TAS1R3 | |
| Adenine SCHEMBL11136514 | 0.87 | TRPM2 (0.49) | FBP1HPRT1DNPH1TRPM2TAS1R3 | |
| Adenine SCHEMBL3921122 | 0.87 | TRPM2 (0.49) | FBP1HPRT1DNPH1TRPM2TAS1R3 | |
| SCHEMBL6906126 | 0.85 | PDPK1 (0.51) | FBP1HPRT1DNPH1TRPM2TAS1R3 | |
| Ribose (Furanose) SCHEMBL831005 | 0.83 | CYP3A4 (0.39) | — | |
| Ribose (Furanose) SCHEMBL7680729 | 0.83 | CYP3A4 (0.39) | — | |
| Mercaptopurine Anhydrous SCHEMBL10522158 | 0.81 | ADORA1 (0.37) | ADORA1P2RY2 | |
| SCHEMBL18241041 | 0.80 | TRPM2 (0.47) | TRPM2P2RY2P2RY1MACROD2SIRT6 | |
| Purine SCHEMBL11573661 | 0.80 | P2RX3 (0.45) | FBP1HPRT1DNPH1TRPM2TAS1R3 | |
| SCHEMBL11011378 | 0.80 | FBP1 (0.45) | FBP1HPRT1DNPH1TRPM2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554363-B1 | ALTERATION OF RATE AND CHARACTER OF HAIR GROWTH | HANDELMAN JOSEPH H (US) | 1998-06-24 | — | — | EP | claimed |