Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224096 | 0.84 | RECQL (0.72) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL27158696 | 0.84 | RECQL (0.72) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL5032754 | 0.84 | RECQL (0.72) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL166780 | 0.84 | RECQL (0.72) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL30752458 | 0.82 | RECQL (0.70) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL22511016 | 0.82 | RECQL (0.70) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL1915838 | 0.81 | RECQL (0.69) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL1915837 | 0.81 | RECQL (0.69) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL1915834 | 0.81 | RECQL (0.69) | RECQLAKR1C3MMECYP3A4CYP2C9 | |
| SCHEMBL1325523 | 0.81 | RECQL (0.68) | RECQLAKR1C3MMECYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PC, PCK2, CS | RECQL 868/4885AKR1C3 634/4885MME 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.