Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 11/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2708721 | 0.79 | ALPL (0.49) | CA1CA2DRD2DRD3 | |
| SCHEMBL2707194 | 0.78 | PDE4A (0.39) | PDE4APDE4CPDE4DSLC40A1PIK3CA | |
| SCHEMBL2030084 | 0.78 | ALDH1A1 (0.49) | PDE4APDE4CPDE4DSLC40A1CA1 | |
| SCHEMBL169540 | 0.76 | PDE4A (0.48) | PDE4APDE4CPDE4DSLC40A1CA1 | |
| SCHEMBL38652754 | 0.76 | ACP1 (0.39) | ACP1 | |
| SCHEMBL8404767 | 0.75 | PDE4A (0.48) | PDE4APDE4CPDE4DSLC40A1METAP2 | |
| SCHEMBL30344840 | 0.75 | CYP3A4 (0.52) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL1543342 | 0.75 | CYP3A4 (0.52) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL14686182 | 0.74 | ACP1 (0.43) | ACP1FEN1METAP2METAP1 | |
| SCHEMBL18796126 | 0.73 | RIPK1 (0.47) | FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |