Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | USP2 | O75604 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 3/20 | 0.36 |
| ▸ | CASP7 | P55210 | 3/20 | 0.36 |
| ▸ | USP1 | O94782 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8579856 | 0.91 | MAPK8 (0.35) | SMOMAPK8MAPK10ALDH1A1CYP1A2 | |
| SCHEMBL1845608 | 0.86 | ALDH1A1 (0.38) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL1845477 | 0.83 | ALDH1A1 (0.49) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL1846364 | 0.82 | LMNA (0.42) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL1844792 | 0.81 | POLB (0.43) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL1848137 | 0.79 | KDM4E (0.51) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL1848688 | 0.79 | ALDH1A1 (0.37) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL1847339 | 0.79 | ALDH1A1 (0.48) | ALDH1A1CYP1A2HSD17B10USP2CASP1 | |
| SCHEMBL8809486 | 0.76 | PTPN11 (0.48) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL1848808 | 0.76 | SMO (0.46) | SMOALDH1A1CYP1A2HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5976523-A | PIPERIDINE- OR PIPERAZINE-SUBSTITUTED PYRROLOPYRIMIDINES | MITSUI PHARMACEUTICALS, INC. (JP) | 1999-11-02 | — | — | US | claimed |
| US-20230302000-A1 | COMBINATION DRUG TREATMENT TO INCREASE NEUROGENESIS FOR NEUROLOGICAL DISORDERS | Progenicyte Therapeutics, Inc. (US) | 2023-09-28 | — | — | US | disclosed |
| US-20210046079-A1 | COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2021-02-18 | — | — | US | disclosed |
| US-20090087462-A1 | Use of pyrimidine derivatives for cosmetic purposes | TREMBLEY MARCELLA | 2009-04-02 | — | — | US | disclosed |
| EP-1890673-A1 | USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES | DSMIP Assets B.V. (NL) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133876-A1 | USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES | DSM IP ASSETS B.V. (NL) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210046079-A1 | COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS | PSEN1, PSEN2, NES | SMO 1060/4885MAPK8 538/4885MAPK10 1229/4885 |
| US-20090087462-A1 | Use of pyrimidine derivatives for cosmetic purposes | TYMP, TYMS, UNG | SMO 582/4885MAPK8 3133/4885MAPK10 3439/4885 |
| US-20230302000-A1 | COMBINATION DRUG TREATMENT TO INCREASE NEUROGENESIS FOR NEUROLOGICAL DISORDERS | NES, PSEN1, PSEN2 | SMO 123/4885MAPK8 26/4885MAPK10 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.