SCHEMBL4293698

SCHEMBL4293698

C=C(C)c1ccc(C(=O)Nc2ccc(NC(=O)c3ccc(C(=C)C)cc3)c3c2C(=O)c2ccccc2C3=O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.62
KMT2A Q03164 4/20 0.62
MMP14 P50281 1/20 0.62
CYP1A2 P05177 1/20 0.55
TSHR P16473 1/20 0.55
MAOA P21397 1/20 0.50
TERT O14746 4/20 0.47
CASP3 P42574 2/20 0.47
POLB P06746 2/20 0.46
BLM P54132 2/20 0.46
RXFP1 Q9HBX9 2/20 0.46
CCR6 P51684 1/20 0.46
APAF1 O14727 1/20 0.44
MITF O75030 1/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4296451 0.90 MAOA (0.65) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL4296856 0.88 MAOA (0.57) MEN1KMT2AMMP14MAOATERT
SCHEMBL8426998 0.88 MEN1 (0.65) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL30544874 0.84 MEN1 (0.82) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL6419867 0.84 MEN1 (0.82) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL6422471 0.82 MEN1 (0.65) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL11139038 0.82 MEN1 (0.58) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL4299603 0.81 MEN1 (0.64) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL14600815 0.80 MEN1 (0.76) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL9174800 0.80 MEN1 (0.76) MEN1KMT2AMMP14CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS MENICON CO., LTD. (JP) 2013-08-08 US disclosed
EP-2581394-A1 IONIC COMPOUND, COMPOSITION, CURED PRODUCT, HYDROGEL, AND OCULAR LENS Menicon Co., Ltd. (JP) 2013-04-17 EP disclosed
EP-1696257-B1 CONTACT LENS MATERIAL MENICON CO LTD (JP) 2012-11-21 EP disclosed
US-20090247662-A1 Contact Lens Material MATSUMOTO MASAHIRO 2009-10-01 US disclosed
US-20070149699-A1 Contact lens material MENICON CO., LTD. (JP) 2007-06-28 US disclosed
EP-1696257-A1 CONTACT LENS MATERIAL MENICON CO., LTD. (JP) 2006-08-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS CRYZ, CRYAA, VIL1 MEN1 1583/4885KMT2A 3332/4885MMP14 1405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.