Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2942179 | 0.95 | HTR4 (0.51) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7307824 | 0.94 | HTR4 (0.49) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL9704182 | 0.92 | HTR4 (0.63) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7308950 | 0.90 | KDM1A (0.46) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7304868 | 0.87 | SLC6A2 (0.47) | SLC6A2SLC6A3PRMT6SLC6A4CARM1 | |
| SCHEMBL7303226 | 0.87 | CYP2C9 (0.49) | HTR4CYP1A2CYP2C9ALOX15NFKB1 | |
| SCHEMBL7300755 | 0.84 | KDM4E (0.46) | HTR4SLC6A2SLC6A3AGTR1KDM4E | |
| SCHEMBL7309279 | 0.84 | KDM1A (0.45) | HTR4CYP1A2CYP2C9KDM1ASLC6A2 | |
| SCHEMBL7304670 | 0.83 | KDM1A (0.46) | KDM1AAGTR1KDM4EMAPTHTR7 | |
| SCHEMBL9341470 | 0.82 | HTR4 (0.50) | HTR4PMP22NPSR1KCNH2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | claimed |
| WO-1992014727-A1 | 3-PIPERIDINYLMETHYLCARBOXYLATE SUBSTITUTED INDOLES | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | claimed |
| US-8829028-B2 | 5-HT4 receptor antagonists for the treatment of heart failure | SERODUS AS (NO) | 2014-09-09 | — | — | US | disclosed |
| US-20090169545-A1 | 5-HT4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE | SERODUS AS (NO) | 2009-07-02 | — | — | US | disclosed |
| US-20060094715-A1 | 5-Ht4 receptor antagonists for the treatment of heart failure | SERODUS AS (NO) | 2006-05-04 | — | — | US | disclosed |