Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 3/20 | 0.65 |
| ▸ | VKORC1 | Q9BQB6 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALB | P02768 | 1/20 | 0.56 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354054 | 0.86 | NQO1 (0.67) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL7352699 | 0.85 | CYP2C9 (0.69) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL7351018 | 0.84 | NQO1 (0.61) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL14078663 | 0.82 | CYP2C9 (0.72) | NQO1VKORC1CYP2C9CRHBPCASP7 | |
| SCHEMBL14078661 | 0.81 | NQO1 (0.73) | NQO1VKORC1CYP2C9CRHBPCASP7 | |
| SCHEMBL1647999 | 0.81 | CYP2C9 (0.66) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL7358027 | 0.81 | NQO1 (0.64) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL7358731 | 0.79 | NQO1 (0.65) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL8042698 | 0.79 | CYP2C9 (0.86) | NQO1VKORC1CYP2C9KDM4EALDH1A1 | |
| SCHEMBL7072964 | 0.78 | NQO1 (0.60) | NQO1VKORC1CYP2C9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | MMP9, MMP10, MMP17 | NQO1 261/4885VKORC1 635/4885CYP2C9 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.