Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4301800 | 0.93 | DDR1 (0.39) | SLC6A9TRPV1NPY2RCACNA1BHCRTR1 | |
| SCHEMBL4009200 | 0.87 | ABCB1 (0.40) | TRPV4NPY2RHTTMEN1POLB | |
| SCHEMBL4006854 | 0.84 | ALDH1A1 (0.37) | HCRTR1HCRTR2MAPT | |
| SCHEMBL4309250 | 0.83 | TAS1R3 (0.37) | SLC6A9MAPT | |
| SCHEMBL4003450 | 0.83 | HCRTR1 (0.36) | HCRTR1HCRTR2MAPTCYP3A4CYP2C9 | |
| SCHEMBL4005617 | 0.83 | ITGB1 (0.36) | KDM4ERXFP1MAPTPOLB | |
| SCHEMBL4005126 | 0.82 | HSD11B1 (0.34) | KDM4EMAPTCYP3A4 | |
| SCHEMBL4010758 | 0.81 | ALDH1A1 (0.37) | KDM4EMAPTMEN1POLBCYP2C9 | |
| SCHEMBL4009205 | 0.81 | ITGB1 (0.38) | MAPT | |
| SCHEMBL4006080 | 0.81 | CYP3A4 (0.39) | KDM4EHTTMAPTMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |