Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | REN | P00797 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4287015 | 0.84 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL4284650 | 0.77 | CA1 (0.32) | CA1CA2CA4CA9 | |
| Hydrochloric Acid SCHEMBL4295188 | 0.73 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPK1POLBRAB9A | |
| Hydrochloric Acid SCHEMBL4287846 | 0.73 | SMN1; SMN2 (0.44) | ALDH1A1HPGDSMN1; SMN2POLBRAB9A | |
| Hydrochloric Acid SCHEMBL4285632 | 0.73 | GAA (0.43) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL4284863 | 0.73 | GAA (0.40) | ALDH1A1HPGDSMN1; SMN2MAPK1POLB | |
| SCHEMBL4289003 | 0.71 | HTR1A (0.43) | ALDH1A1SMN1; SMN2MAPTCA1CA2 | |
| SCHEMBL4293400 | 0.69 | NPC1 (0.34) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9211341 | 0.69 | PDK1 (0.59) | PDK1ALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL4285115 | 0.69 | CA1 (0.35) | RENCA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | PDK1 1156/4885ALDH1A1 388/4885HPGD 106/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | PDK1 1156/4885ALDH1A1 388/4885HPGD 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.