Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297603 | 1.00 | TRPA1 (0.43) | TRPA1CYP19A1CYP11B2HPGDSMN1; SMN2 | |
| SCHEMBL31059316 | 0.81 | AKR1C3 (0.52) | TRPA1SMN1; SMN2CYP1A2NPC1RAB9A | |
| SCHEMBL4289163 | 0.80 | TRPA1 (0.68) | TRPA1CYP19A1CYP11B2HPGDSMN1; SMN2 | |
| SCHEMBL4289159 | 0.80 | TRPA1 (0.68) | TRPA1CYP19A1CYP11B2HPGDSMN1; SMN2 | |
| SCHEMBL3668618 | 0.79 | TRPA1 (0.61) | TRPA1CYP19A1CYP11B2SMN1; SMN2KDM4E | |
| SCHEMBL3668616 | 0.79 | TRPA1 (0.61) | TRPA1CYP19A1CYP11B2SMN1; SMN2KDM4E | |
| SCHEMBL31059333 | 0.79 | ALDH1A1 (0.55) | TRPA1HPGDKDM4ECYP1A2RAB9A | |
| SCHEMBL28287608 | 0.73 | SMN1; SMN2 (0.44) | CYP19A1CYP11B2HPGDSMN1; SMN2KDM4E | |
| SCHEMBL30930817 | 0.73 | SMN1; SMN2 (0.44) | CYP19A1CYP11B2HPGDSMN1; SMN2KDM4E | |
| SCHEMBL31059321 | 0.72 | FBP1 (0.47) | TRPA1CYP19A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751850-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20150065538-A1 | TRPA1 ANTAGONISTS | ABBVIE INC (US) | 2015-03-05 | — | — | US | disclosed |
| US-8877784-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065538-A1 | TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885CYP19A1 1800/4885CYP11B2 1513/4885 |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885CYP19A1 1800/4885CYP11B2 1513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.