SCHEMBL4297642

SCHEMBL4297642

COc1c(O)cc(C(C)(C)C)cc1C(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.46
HPGD P15428 2/20 0.46
LMNA P02545 2/20 0.46
CYP3A4 P08684 2/20 0.46
TP53 P04637 1/20 0.46
TDP1 Q9NUW8 3/20 0.45
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
ALDH1A1 P00352 5/20 0.43
CYP1A2 P05177 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MAPT P10636 1/20 0.43
ATP2A2 P16615 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ATP2A3 Q93084 1/20 0.43
HSD17B10 Q99714 2/20 0.42
RARG P13631 1/20 0.42
RXRA P19793 1/20 0.42
PPARG P37231 1/20 0.42
GABRA1 P14867 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11871934 0.87 TDP1 (0.58) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL2947022 0.85 PTGS2 (0.47) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL7843399 0.80 TPMT (0.50) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL18456401 0.79 RXRA (0.45) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL13688744 0.79 ALDH1A1 (0.42) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL14817161 0.79 RARG (0.40) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL936302 0.78 RARG (0.41) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL17274610 0.78 HSP90AA1 (0.50) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL6676891 0.78 PTGS2 (0.42) ALOX15HPGDLMNACYP3A4TP53
SCHEMBL10019863 0.78 CYP3A4 (0.42) ALOX15HPGDLMNACYP3A4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090305339-A1 Polypeptides With Laccase Activity VIALACTIA BIOSCIENCES (NZ) LIMITED (NZ) 2009-12-10 US disclosed
EP-1996702-A1 POLYPEPTIDES WITH LACCASE ACTIVITY Vialactia Bioscience (NZ) Limited (NZ) 2008-12-03 EP disclosed
US-20080125531-A1 Polymerizable Composition, Thermoplastic Resin Composition, Crosslinked Resin, And Crosslinked Resin Composite Materials ZEON COROPRATION (JP) 2008-05-29 US disclosed
CN-100365039-C Polymerizable composition, thermoplastic resin composition, crosslinked resin, and crosslinked resin composite materials ZEON CORP (JP) 2008-01-30 CN disclosed
WO-2007096184-A1 POLYPEPTIDES WITH LACCASE ACTIVITY VIALACTIA BIOSCIENCES (NZ) LIMITED (NZ) 2007-08-30 WO disclosed
EP-1826266-A1 Polypeptides with laccase activity Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2007-08-29 EP disclosed
CN-1764681-A Polymerizable composition, thermoplastic resin composition, crosslinked resin, and crosslinked resin composite materials ZEON CORP (JP) 2006-04-26 CN disclosed
EP-1589054-A1 POLYMERIZABLE COMPOSITION, THERMOPLASTIC RESIN COMPOSITION, CROSSLINKED RESIN, AND CROSSLINKED RESIN COMPOSITE MATERIALS Zeon Corporation (JP) 2005-10-26 EP disclosed